Impact of platelets and serotonin on liver regeneration after living donor hepatectomy

Tomoharu Yoshizumi, shinji itoh, D. Imai, Toru Ikegami, M. Ninomiya, T. Iguchi, Norifumi Harimoto, kazuki takeishi, Yasue Kimura, H. Uchiyama, Yuji Soejima, Tetsuo Ikeda, H. Kawanaka, K. Shirabe, Yoshihiko Maehara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background Several animal models have revealed that platelet-derived serotonin initiates liver regeneration after hepatectomy. However, there are few reports regarding the effects of serotonin in the clinical setting. The aim of this study was to explore the impact of serotonin and platelets in the early phase after healthy living donor hepatectomy. Study Design Stored samples from 34 living donors who received left lobectomy with caudate lobectomy (LL+C) or right lobectomy (RL) were available in the study. Serum serotonin levels and platelet counts associated with liver regeneration such as whole liver volume and hepatic graft weight (GW) were retrospectively collected from the database and analyzed. Results The remnant liver volume rate of RL grafts was smaller than that of LL+C grafts (45.4% vs 64.7%; P <.001). The regeneration rate at 7 days after surgery did not differ between the 2 groups (123% vs 122%). The serotonin levels and platelet counts decreased after surgery until postoperative day 3, then increased thereafter. The platelet counts and serotonin levels of LL+C donors were significantly higher than those of RL donors. Conclusions Our findings suggest that platelets and serotonin play a pivotal role in initiating liver regeneration in the remnant liver.

Original languageEnglish
Pages (from-to)683-685
Number of pages3
JournalTransplantation Proceedings
Volume47
Issue number3
DOIs
Publication statusPublished - Apr 1 2015

Fingerprint

Liver Regeneration
Living Donors
Hepatectomy
Serotonin
Blood Platelets
Platelet Count
Liver
Transplants
Tissue Donors
Ambulatory Surgical Procedures
Regeneration
Animal Models
Databases
Weights and Measures
Serum

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Impact of platelets and serotonin on liver regeneration after living donor hepatectomy. / Yoshizumi, Tomoharu; itoh, shinji; Imai, D.; Ikegami, Toru; Ninomiya, M.; Iguchi, T.; Harimoto, Norifumi; takeishi, kazuki; Kimura, Yasue; Uchiyama, H.; Soejima, Yuji; Ikeda, Tetsuo; Kawanaka, H.; Shirabe, K.; Maehara, Yoshihiko.

In: Transplantation Proceedings, Vol. 47, No. 3, 01.04.2015, p. 683-685.

Research output: Contribution to journalArticle

Yoshizumi, Tomoharu ; itoh, shinji ; Imai, D. ; Ikegami, Toru ; Ninomiya, M. ; Iguchi, T. ; Harimoto, Norifumi ; takeishi, kazuki ; Kimura, Yasue ; Uchiyama, H. ; Soejima, Yuji ; Ikeda, Tetsuo ; Kawanaka, H. ; Shirabe, K. ; Maehara, Yoshihiko. / Impact of platelets and serotonin on liver regeneration after living donor hepatectomy. In: Transplantation Proceedings. 2015 ; Vol. 47, No. 3. pp. 683-685.
@article{1c9562922fc94744b805c52ef2ce0f28,
title = "Impact of platelets and serotonin on liver regeneration after living donor hepatectomy",
abstract = "Background Several animal models have revealed that platelet-derived serotonin initiates liver regeneration after hepatectomy. However, there are few reports regarding the effects of serotonin in the clinical setting. The aim of this study was to explore the impact of serotonin and platelets in the early phase after healthy living donor hepatectomy. Study Design Stored samples from 34 living donors who received left lobectomy with caudate lobectomy (LL+C) or right lobectomy (RL) were available in the study. Serum serotonin levels and platelet counts associated with liver regeneration such as whole liver volume and hepatic graft weight (GW) were retrospectively collected from the database and analyzed. Results The remnant liver volume rate of RL grafts was smaller than that of LL+C grafts (45.4{\%} vs 64.7{\%}; P <.001). The regeneration rate at 7 days after surgery did not differ between the 2 groups (123{\%} vs 122{\%}). The serotonin levels and platelet counts decreased after surgery until postoperative day 3, then increased thereafter. The platelet counts and serotonin levels of LL+C donors were significantly higher than those of RL donors. Conclusions Our findings suggest that platelets and serotonin play a pivotal role in initiating liver regeneration in the remnant liver.",
author = "Tomoharu Yoshizumi and shinji itoh and D. Imai and Toru Ikegami and M. Ninomiya and T. Iguchi and Norifumi Harimoto and kazuki takeishi and Yasue Kimura and H. Uchiyama and Yuji Soejima and Tetsuo Ikeda and H. Kawanaka and K. Shirabe and Yoshihiko Maehara",
year = "2015",
month = "4",
day = "1",
doi = "10.1016/j.transproceed.2014.11.050",
language = "English",
volume = "47",
pages = "683--685",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Impact of platelets and serotonin on liver regeneration after living donor hepatectomy

AU - Yoshizumi, Tomoharu

AU - itoh, shinji

AU - Imai, D.

AU - Ikegami, Toru

AU - Ninomiya, M.

AU - Iguchi, T.

AU - Harimoto, Norifumi

AU - takeishi, kazuki

AU - Kimura, Yasue

AU - Uchiyama, H.

AU - Soejima, Yuji

AU - Ikeda, Tetsuo

AU - Kawanaka, H.

AU - Shirabe, K.

AU - Maehara, Yoshihiko

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Background Several animal models have revealed that platelet-derived serotonin initiates liver regeneration after hepatectomy. However, there are few reports regarding the effects of serotonin in the clinical setting. The aim of this study was to explore the impact of serotonin and platelets in the early phase after healthy living donor hepatectomy. Study Design Stored samples from 34 living donors who received left lobectomy with caudate lobectomy (LL+C) or right lobectomy (RL) were available in the study. Serum serotonin levels and platelet counts associated with liver regeneration such as whole liver volume and hepatic graft weight (GW) were retrospectively collected from the database and analyzed. Results The remnant liver volume rate of RL grafts was smaller than that of LL+C grafts (45.4% vs 64.7%; P <.001). The regeneration rate at 7 days after surgery did not differ between the 2 groups (123% vs 122%). The serotonin levels and platelet counts decreased after surgery until postoperative day 3, then increased thereafter. The platelet counts and serotonin levels of LL+C donors were significantly higher than those of RL donors. Conclusions Our findings suggest that platelets and serotonin play a pivotal role in initiating liver regeneration in the remnant liver.

AB - Background Several animal models have revealed that platelet-derived serotonin initiates liver regeneration after hepatectomy. However, there are few reports regarding the effects of serotonin in the clinical setting. The aim of this study was to explore the impact of serotonin and platelets in the early phase after healthy living donor hepatectomy. Study Design Stored samples from 34 living donors who received left lobectomy with caudate lobectomy (LL+C) or right lobectomy (RL) were available in the study. Serum serotonin levels and platelet counts associated with liver regeneration such as whole liver volume and hepatic graft weight (GW) were retrospectively collected from the database and analyzed. Results The remnant liver volume rate of RL grafts was smaller than that of LL+C grafts (45.4% vs 64.7%; P <.001). The regeneration rate at 7 days after surgery did not differ between the 2 groups (123% vs 122%). The serotonin levels and platelet counts decreased after surgery until postoperative day 3, then increased thereafter. The platelet counts and serotonin levels of LL+C donors were significantly higher than those of RL donors. Conclusions Our findings suggest that platelets and serotonin play a pivotal role in initiating liver regeneration in the remnant liver.

UR - http://www.scopus.com/inward/record.url?scp=84928328017&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928328017&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2014.11.050

DO - 10.1016/j.transproceed.2014.11.050

M3 - Article

VL - 47

SP - 683

EP - 685

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 3

ER -