Impact of serum uric acid on incident hypertension in a worksite population of Japanese men

Yasuo Kansui, Kiyoshi Matsumura, Yuki Morinaga, Minako Inoue, Kanako Kiyohara, Yuko Ohta, Kenichi Goto, Toshio Ohtsubo, Hiroaki Ooboshi, Takanari Kitazono

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: Higher levels of serum uric acid are associated with an increased risk of cardiovascular diseases, which may be confounded by comorbidities. We investigated the effects of serum uric acid on the risk of hypertension in Japanese men at a worksite. Methods: We evaluated a total of 2335 Japanese male workers without hypertension who ranged in age from 18 to 64 years at a worksite in 2009. These men were followed for 6 years from 2009 to 2015. Results: During the follow-up period, 380 individuals developed hypertension. The odds ratio for the incident hypertension was estimated according to quartiles of serum uric acid levels of 5.1 or less, 5.2-5.8, 5.9-6.6, and at least 6.7mg/dl. The multivariable-adjusted risk of incident hypertension was significantly higher in the highest serum uric acid quartile than in the lowest: odds ratio 1.00 (reference) for the lowest quartile, 1.34 (0.91-1.97) for the second quartile, 1.42 (0.97-2.06) for the third quartile, and 1.65 (1.14-2.40) for the highest quartile. In stratified analyses, the association between serum uric acid and incident hypertension was significant in the patients of aged below 45 years and without comorbidities, namely diabetes and low levels of high-density lipoprotein-cholesterol. Conclusions: Serum uric acid levels were associated with the future incidence of hypertension, and the association was observed in the younger individuals, those without diabetes, and those with preserved high-density lipoprotein cholesterol levels in a worksite population of Japanese men.

Original languageEnglish
Pages (from-to)1499-1505
Number of pages7
JournalJournal of hypertension
Volume36
Issue number7
DOIs
Publication statusPublished - Jul 1 2018

Fingerprint

Uric Acid
Workplace
Hypertension
Serum
Population
HDL Cholesterol
Comorbidity
Odds Ratio
Cardiovascular Diseases
Incidence

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Impact of serum uric acid on incident hypertension in a worksite population of Japanese men. / Kansui, Yasuo; Matsumura, Kiyoshi; Morinaga, Yuki; Inoue, Minako; Kiyohara, Kanako; Ohta, Yuko; Goto, Kenichi; Ohtsubo, Toshio; Ooboshi, Hiroaki; Kitazono, Takanari.

In: Journal of hypertension, Vol. 36, No. 7, 01.07.2018, p. 1499-1505.

Research output: Contribution to journalArticle

Kansui, Y, Matsumura, K, Morinaga, Y, Inoue, M, Kiyohara, K, Ohta, Y, Goto, K, Ohtsubo, T, Ooboshi, H & Kitazono, T 2018, 'Impact of serum uric acid on incident hypertension in a worksite population of Japanese men', Journal of hypertension, vol. 36, no. 7, pp. 1499-1505. https://doi.org/10.1097/HJH.0000000000001743
Kansui, Yasuo ; Matsumura, Kiyoshi ; Morinaga, Yuki ; Inoue, Minako ; Kiyohara, Kanako ; Ohta, Yuko ; Goto, Kenichi ; Ohtsubo, Toshio ; Ooboshi, Hiroaki ; Kitazono, Takanari. / Impact of serum uric acid on incident hypertension in a worksite population of Japanese men. In: Journal of hypertension. 2018 ; Vol. 36, No. 7. pp. 1499-1505.
@article{5c8bb5816524450b9a50f6ad56865818,
title = "Impact of serum uric acid on incident hypertension in a worksite population of Japanese men",
abstract = "Objective: Higher levels of serum uric acid are associated with an increased risk of cardiovascular diseases, which may be confounded by comorbidities. We investigated the effects of serum uric acid on the risk of hypertension in Japanese men at a worksite. Methods: We evaluated a total of 2335 Japanese male workers without hypertension who ranged in age from 18 to 64 years at a worksite in 2009. These men were followed for 6 years from 2009 to 2015. Results: During the follow-up period, 380 individuals developed hypertension. The odds ratio for the incident hypertension was estimated according to quartiles of serum uric acid levels of 5.1 or less, 5.2-5.8, 5.9-6.6, and at least 6.7mg/dl. The multivariable-adjusted risk of incident hypertension was significantly higher in the highest serum uric acid quartile than in the lowest: odds ratio 1.00 (reference) for the lowest quartile, 1.34 (0.91-1.97) for the second quartile, 1.42 (0.97-2.06) for the third quartile, and 1.65 (1.14-2.40) for the highest quartile. In stratified analyses, the association between serum uric acid and incident hypertension was significant in the patients of aged below 45 years and without comorbidities, namely diabetes and low levels of high-density lipoprotein-cholesterol. Conclusions: Serum uric acid levels were associated with the future incidence of hypertension, and the association was observed in the younger individuals, those without diabetes, and those with preserved high-density lipoprotein cholesterol levels in a worksite population of Japanese men.",
author = "Yasuo Kansui and Kiyoshi Matsumura and Yuki Morinaga and Minako Inoue and Kanako Kiyohara and Yuko Ohta and Kenichi Goto and Toshio Ohtsubo and Hiroaki Ooboshi and Takanari Kitazono",
year = "2018",
month = "7",
day = "1",
doi = "10.1097/HJH.0000000000001743",
language = "English",
volume = "36",
pages = "1499--1505",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Impact of serum uric acid on incident hypertension in a worksite population of Japanese men

AU - Kansui, Yasuo

AU - Matsumura, Kiyoshi

AU - Morinaga, Yuki

AU - Inoue, Minako

AU - Kiyohara, Kanako

AU - Ohta, Yuko

AU - Goto, Kenichi

AU - Ohtsubo, Toshio

AU - Ooboshi, Hiroaki

AU - Kitazono, Takanari

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Objective: Higher levels of serum uric acid are associated with an increased risk of cardiovascular diseases, which may be confounded by comorbidities. We investigated the effects of serum uric acid on the risk of hypertension in Japanese men at a worksite. Methods: We evaluated a total of 2335 Japanese male workers without hypertension who ranged in age from 18 to 64 years at a worksite in 2009. These men were followed for 6 years from 2009 to 2015. Results: During the follow-up period, 380 individuals developed hypertension. The odds ratio for the incident hypertension was estimated according to quartiles of serum uric acid levels of 5.1 or less, 5.2-5.8, 5.9-6.6, and at least 6.7mg/dl. The multivariable-adjusted risk of incident hypertension was significantly higher in the highest serum uric acid quartile than in the lowest: odds ratio 1.00 (reference) for the lowest quartile, 1.34 (0.91-1.97) for the second quartile, 1.42 (0.97-2.06) for the third quartile, and 1.65 (1.14-2.40) for the highest quartile. In stratified analyses, the association between serum uric acid and incident hypertension was significant in the patients of aged below 45 years and without comorbidities, namely diabetes and low levels of high-density lipoprotein-cholesterol. Conclusions: Serum uric acid levels were associated with the future incidence of hypertension, and the association was observed in the younger individuals, those without diabetes, and those with preserved high-density lipoprotein cholesterol levels in a worksite population of Japanese men.

AB - Objective: Higher levels of serum uric acid are associated with an increased risk of cardiovascular diseases, which may be confounded by comorbidities. We investigated the effects of serum uric acid on the risk of hypertension in Japanese men at a worksite. Methods: We evaluated a total of 2335 Japanese male workers without hypertension who ranged in age from 18 to 64 years at a worksite in 2009. These men were followed for 6 years from 2009 to 2015. Results: During the follow-up period, 380 individuals developed hypertension. The odds ratio for the incident hypertension was estimated according to quartiles of serum uric acid levels of 5.1 or less, 5.2-5.8, 5.9-6.6, and at least 6.7mg/dl. The multivariable-adjusted risk of incident hypertension was significantly higher in the highest serum uric acid quartile than in the lowest: odds ratio 1.00 (reference) for the lowest quartile, 1.34 (0.91-1.97) for the second quartile, 1.42 (0.97-2.06) for the third quartile, and 1.65 (1.14-2.40) for the highest quartile. In stratified analyses, the association between serum uric acid and incident hypertension was significant in the patients of aged below 45 years and without comorbidities, namely diabetes and low levels of high-density lipoprotein-cholesterol. Conclusions: Serum uric acid levels were associated with the future incidence of hypertension, and the association was observed in the younger individuals, those without diabetes, and those with preserved high-density lipoprotein cholesterol levels in a worksite population of Japanese men.

UR - http://www.scopus.com/inward/record.url?scp=85048330006&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048330006&partnerID=8YFLogxK

U2 - 10.1097/HJH.0000000000001743

DO - 10.1097/HJH.0000000000001743

M3 - Article

C2 - 29746372

AN - SCOPUS:85048330006

VL - 36

SP - 1499

EP - 1505

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 7

ER -