Impact of single nucleotide polymorphisms in glutathione S transferase gene GSTP1 in the treatment with oxaliplatin based chemotherapy

Eiji Oki, Yoshihiro Kakeji, Kippei Ohgaki, Kohji Saeki, Masaru Morita, Yasunori Emi, Yoshihiko Maehara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Oxaliplatin has been the main treatment of choice in colorectal cancer in advanced settings. However, cellular mechanisms for the uptake, intracellular distribution and efflux of oxaliplatin are unknown. GST(glutathione S transferase)is member of a superfamily of metabolic enzymes that play an important role in the cell defense system. Current data suggest that GST-pi is associated with increased resistance to platinum-based chemotherapy. Specific roles for the single nucleotide polymorphisms in GST-pi gene GSTP1 in the treatment with oxaliplatin based chemotherapy, have been demonstrated in recent years.

Original languageEnglish
Pages (from-to)1094-1096
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume35
Issue number7
Publication statusPublished - Jul 2008

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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