TY - JOUR
T1 - Impact of smoking on the age at diagnosis of upper tract urothelial carcinoma
T2 - Subanalysis of the Japanese Urological Association multi-institutional national database
AU - Cancer Registration Committee of the Japanese Urological Association
AU - Miyazaki, Jun
AU - Nishiyama, Hiroyuki
AU - Fujimoto, Hiroyuki
AU - Ohyama, Chikara
AU - Koie, Takuya
AU - Hinotsu, Shiro
AU - Kikuchi, Eiji
AU - Sakura, Mizuaki
AU - Inokuchi, Junichi
AU - Hara, Tomohiko
AU - Kanayama, Hiro omi
AU - Miki, Tsuneharu
AU - Suzuki, Kazuhiro
AU - Eto, Masatoshi
AU - Nakanishi, Hiroyuki
AU - Fukumori, Tomoharu
AU - Naito, Seiji
N1 - Publisher Copyright:
© 2015 The Japanese Urological Association.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2015/11
Y1 - 2015/11
N2 - Objectives: To examine the influence of smoking history on the diagnosis and other tumor characteristics of upper tract urothelial carcinoma in Japan. Methods: A total of 1509 patients with upper tract urothelial carcinoma who were diagnosed in 2005 from 348 Japanese institutions were registered using the multi-institutional national database of the Japanese Urological Association and included in this analysis. Clinical data of the patients were collected in 2011. The associations between the patients' self-reported smoking history and their age at the diagnosis of upper tract urothelial carcinoma, sex, pathological T stage and tumor grade were analyzed. Results: The mean age at the diagnosis of upper tract urothelial carcinoma was approximately 5 years earlier for the 238 current smokers than for the 618 current non-smokers (P < 0.0001). Similar associations between smoking and the early diagnosis of upper tract urothelial carcinoma were shown in the sex subgroups and in subgroups stratified by pathological T stages. Among the current smokers, the age at diagnosis for the smoking ≥20 cigarettes per day group was 6.5 years lower than that of the <20 cigarettes per day group, which was significantly different (P < 0.0001). Conclusion: Current smoking is a significant risk factor for the earlier diagnosis of upper tract urothelial carcinoma. The finding is important from the perspective of both healthcare and medical economies.
AB - Objectives: To examine the influence of smoking history on the diagnosis and other tumor characteristics of upper tract urothelial carcinoma in Japan. Methods: A total of 1509 patients with upper tract urothelial carcinoma who were diagnosed in 2005 from 348 Japanese institutions were registered using the multi-institutional national database of the Japanese Urological Association and included in this analysis. Clinical data of the patients were collected in 2011. The associations between the patients' self-reported smoking history and their age at the diagnosis of upper tract urothelial carcinoma, sex, pathological T stage and tumor grade were analyzed. Results: The mean age at the diagnosis of upper tract urothelial carcinoma was approximately 5 years earlier for the 238 current smokers than for the 618 current non-smokers (P < 0.0001). Similar associations between smoking and the early diagnosis of upper tract urothelial carcinoma were shown in the sex subgroups and in subgroups stratified by pathological T stages. Among the current smokers, the age at diagnosis for the smoking ≥20 cigarettes per day group was 6.5 years lower than that of the <20 cigarettes per day group, which was significantly different (P < 0.0001). Conclusion: Current smoking is a significant risk factor for the earlier diagnosis of upper tract urothelial carcinoma. The finding is important from the perspective of both healthcare and medical economies.
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U2 - 10.1111/iju.12886
DO - 10.1111/iju.12886
M3 - Article
C2 - 26238570
AN - SCOPUS:84945467635
VL - 22
SP - 1023
EP - 1027
JO - International Journal of Urology
JF - International Journal of Urology
SN - 0919-8172
IS - 11
ER -