Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants

Laila Damiati, Marcus G. Eales, Angela H. Nobbs, Bo Su, Penelope M. Tsimbouri, Manuel Salmeron-Sanchez, Matthew J. Dalby

Research output: Contribution to journalArticle


Titanium (Ti) plays a predominant role as the material of choice in orthopaedic and dental implants. Despite the majority of Ti implants having long-term success, premature failure due to unsuccessful osseointegration leading to aseptic loosening is still too common. Recently, surface topography modification and biological/non-biological coatings have been integrated into orthopaedic/dental implants in order to mimic the surrounding biological environment as well as reduce the inflammation/infection that may occur. In this review, we summarize the impact of various Ti coatings on cell behaviour both in vivo and in vitro. First, we focus on the Ti surface properties and their effects on osteogenesis and then on bacterial adhesion and viability. We conclude from the current literature that surface modification of Ti implants can be generated that offer both osteoinductive and antimicrobial properties.

Original languageEnglish
JournalJournal of Tissue Engineering
Publication statusPublished - Jul 23 2018


All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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