Abstract
Background Epidemiologic studies have elucidated that the 1425G/A single-nucleotide polymorphism (rs2230500 single-nucleotide polymorphism) in exon 9 of the protein kinase C eta (PRKCH) gene is an independent risk factor for ischemic stroke: stroke incidence is significantly higher in the subjects with AA than those with AG or GG genotype. However, its impact on stroke recurrence remains unknown. The aim of the present study was to clarify whether the polymorphism is also a risk factor for recurrent stroke in patients with acute ischemic stroke. Methods We enrolled 2418 consecutive patients with acute and first-ever ischemic stroke and investigated the 1425G/A polymorphism of PRKCH. Patients were followed up for a median of 733 days. The association between the polymorphism and stroke recurrence was investigated using the Cox proportional hazard model. Results In the enrolled patients, the GG genotype was the most prevalent (63%), followed by AG (32%) and AA genotypes (5%). Recurrent stroke occurred in 302 patients during the follow-up period. Kaplan-Meier analyses revealed no difference in the rate of recurrent stroke after first-ever stroke among the 3 genotypes. The incidence of recurrent stroke was not significantly different in patients with AA (hazard ratio [HR] 1.02, 95% confidence interval.59-1.64, P =.94) or AG (HR.89, 95% confidence interval.69-1.14, P =.36) genotypes compared with those with the GG genotype after adjusting for multiple confounders. Conclusions The 1425G/A polymorphism in PRKCH is not a significant predictor of stroke recurrence in patients with acute ischemic stroke during a 2-year follow-up period.
| Original language | English |
|---|---|
| Pages (from-to) | 1356-1361 |
| Number of pages | 6 |
| Journal | Journal of Stroke and Cerebrovascular Diseases |
| Volume | 23 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jul 2014 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Rehabilitation
- Clinical Neurology
- Cardiology and Cardiovascular Medicine
Cite this
Impact of the 1425G/A polymorphism of PRKCH on the recurrence of ischemic stroke : Fukuoka stroke registry. / Matsuo, Ryu; Ago, Tetsuro; Hata, Jun; Kuroda, Junya; Wakisaka, Yoshinobu; Sugimori, Hiroshi; Kitazono, Takanari; Kamouchi, Masahiro.
In: Journal of Stroke and Cerebrovascular Diseases, Vol. 23, No. 6, 07.2014, p. 1356-1361.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of the 1425G/A polymorphism of PRKCH on the recurrence of ischemic stroke
T2 - Fukuoka stroke registry
AU - Matsuo, Ryu
AU - Ago, Tetsuro
AU - Hata, Jun
AU - Kuroda, Junya
AU - Wakisaka, Yoshinobu
AU - Sugimori, Hiroshi
AU - Kitazono, Takanari
AU - Kamouchi, Masahiro
PY - 2014/7
Y1 - 2014/7
N2 - Background Epidemiologic studies have elucidated that the 1425G/A single-nucleotide polymorphism (rs2230500 single-nucleotide polymorphism) in exon 9 of the protein kinase C eta (PRKCH) gene is an independent risk factor for ischemic stroke: stroke incidence is significantly higher in the subjects with AA than those with AG or GG genotype. However, its impact on stroke recurrence remains unknown. The aim of the present study was to clarify whether the polymorphism is also a risk factor for recurrent stroke in patients with acute ischemic stroke. Methods We enrolled 2418 consecutive patients with acute and first-ever ischemic stroke and investigated the 1425G/A polymorphism of PRKCH. Patients were followed up for a median of 733 days. The association between the polymorphism and stroke recurrence was investigated using the Cox proportional hazard model. Results In the enrolled patients, the GG genotype was the most prevalent (63%), followed by AG (32%) and AA genotypes (5%). Recurrent stroke occurred in 302 patients during the follow-up period. Kaplan-Meier analyses revealed no difference in the rate of recurrent stroke after first-ever stroke among the 3 genotypes. The incidence of recurrent stroke was not significantly different in patients with AA (hazard ratio [HR] 1.02, 95% confidence interval.59-1.64, P =.94) or AG (HR.89, 95% confidence interval.69-1.14, P =.36) genotypes compared with those with the GG genotype after adjusting for multiple confounders. Conclusions The 1425G/A polymorphism in PRKCH is not a significant predictor of stroke recurrence in patients with acute ischemic stroke during a 2-year follow-up period.
AB - Background Epidemiologic studies have elucidated that the 1425G/A single-nucleotide polymorphism (rs2230500 single-nucleotide polymorphism) in exon 9 of the protein kinase C eta (PRKCH) gene is an independent risk factor for ischemic stroke: stroke incidence is significantly higher in the subjects with AA than those with AG or GG genotype. However, its impact on stroke recurrence remains unknown. The aim of the present study was to clarify whether the polymorphism is also a risk factor for recurrent stroke in patients with acute ischemic stroke. Methods We enrolled 2418 consecutive patients with acute and first-ever ischemic stroke and investigated the 1425G/A polymorphism of PRKCH. Patients were followed up for a median of 733 days. The association between the polymorphism and stroke recurrence was investigated using the Cox proportional hazard model. Results In the enrolled patients, the GG genotype was the most prevalent (63%), followed by AG (32%) and AA genotypes (5%). Recurrent stroke occurred in 302 patients during the follow-up period. Kaplan-Meier analyses revealed no difference in the rate of recurrent stroke after first-ever stroke among the 3 genotypes. The incidence of recurrent stroke was not significantly different in patients with AA (hazard ratio [HR] 1.02, 95% confidence interval.59-1.64, P =.94) or AG (HR.89, 95% confidence interval.69-1.14, P =.36) genotypes compared with those with the GG genotype after adjusting for multiple confounders. Conclusions The 1425G/A polymorphism in PRKCH is not a significant predictor of stroke recurrence in patients with acute ischemic stroke during a 2-year follow-up period.
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U2 - 10.1016/j.jstrokecerebrovasdis.2013.11.011
DO - 10.1016/j.jstrokecerebrovasdis.2013.11.011
M3 - Article
C2 - 24534126
AN - SCOPUS:84902449157
VL - 23
SP - 1356
EP - 1361
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
SN - 1052-3057
IS - 6
ER -