TY - JOUR
T1 - Impact of the histological type on the prognosis of patients with prenatally diagnosed sacrococcygeal teratomas
T2 - The results of a nationwide Japanese survey
AU - Yoneda, Akihiro
AU - Usui, Noriaki
AU - Taguchi, Tomoaki
AU - Kitano, Yoshihiro
AU - Sago, Haruhiko
AU - Kanamori, Yutaka
AU - Nakamura, Tomoo
AU - Nosaka, Shunsuke
AU - Oba, Mari S.
PY - 2013/11
Y1 - 2013/11
N2 - Purpose: To identify the impact of the histological diagnosis on the prognosis of prenatally diagnosed sacrococcygeal teratoma (SCT), we analyzed the data obtained during prenatal surveillance and assessed the postnatal outcomes in a large cohort of fetuses with SCT in Japan. Methods: A nationwide retrospective cohort study was conducted among 97 fetuses prenatally diagnosed with SCT between 2000 and 2009. Of these, 84 had a histological diagnosis. In addition, we conducted a second surveillance program of the prognosis of 72 patients who were reported to be alive at the initial surveillance conducted 2 years previously. Results: The tumors comprised 51 (61 %) mature teratomas, 33 (39 %) immature teratomas and 0 (0 %) malignant teratomas. Immature teratomas were also associated with a significantly higher mortality rate (immature teratomas: 8/31, mature teratomas: 2/48). Late recurrence was observed in six of 72 cases (8.3 %). Among these six cases, recurrence with a malignant component was observed in four patients. All six patients were successfully treated. Conclusions: Mature teratoma was the most common histological type observed in this study. The patients with immature teratomas exhibited an increased risk of mortality. Late recurrence was observed in 8.3 % of the cases.
AB - Purpose: To identify the impact of the histological diagnosis on the prognosis of prenatally diagnosed sacrococcygeal teratoma (SCT), we analyzed the data obtained during prenatal surveillance and assessed the postnatal outcomes in a large cohort of fetuses with SCT in Japan. Methods: A nationwide retrospective cohort study was conducted among 97 fetuses prenatally diagnosed with SCT between 2000 and 2009. Of these, 84 had a histological diagnosis. In addition, we conducted a second surveillance program of the prognosis of 72 patients who were reported to be alive at the initial surveillance conducted 2 years previously. Results: The tumors comprised 51 (61 %) mature teratomas, 33 (39 %) immature teratomas and 0 (0 %) malignant teratomas. Immature teratomas were also associated with a significantly higher mortality rate (immature teratomas: 8/31, mature teratomas: 2/48). Late recurrence was observed in six of 72 cases (8.3 %). Among these six cases, recurrence with a malignant component was observed in four patients. All six patients were successfully treated. Conclusions: Mature teratoma was the most common histological type observed in this study. The patients with immature teratomas exhibited an increased risk of mortality. Late recurrence was observed in 8.3 % of the cases.
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U2 - 10.1007/s00383-013-3384-7
DO - 10.1007/s00383-013-3384-7
M3 - Article
C2 - 23982387
AN - SCOPUS:84886085960
VL - 29
SP - 1119
EP - 1125
JO - Pediatric Surgery International
JF - Pediatric Surgery International
SN - 0179-0358
IS - 11
ER -