Impact of time-of-flight PET/CT with a large axial field of view for reducing whole-body acquisition time

Go Akamatsu, Koji Uba, Takafumi Taniguchi, Katsuhiko Mitsumoto, Akihiro Narisue, Yuji Tsutsui, Masayuki Sasaki

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The aim of this study was to evaluate the imaging performance of 39- and 52-ring time-of-flight (TOF) PET/CT scanners. We also assessed the potential of reducing the scanning time using a 52-ring TOF PET/CT scanner. Methods: PET/CT scanners with 39- and 52-ring lutetium oxyorthosilicate detectors were evaluated. The axial fields of view were 16.2 and 21.6 cm, respectively. We used a National Electrical Manufacturers Association International Electrotechnical Commission body phantom filled with an 18F solution containing background activity of 5.31 and 2.65 kBq/mL for the studies. The sphere-to-background ratio was 4:1. The PET data were acquired for 10 min in 3-dimensional list mode and then reconstructed with both ordered-subsets reconstruction maximization and ordered-subsets reconstruction maximization plus point-spread function plus time-of-flight algorithms. PET images with different acquisition times were reconstructed (from 1 to 10 min). The image quality was physically assessed using the sensitivity, noise-equivalent counting rate, coefficient of variation of background activity, and relative recovery coefficient. Results: The total system sensitivities of the 39- and 52-ring scanners were 5.6 and 9.3 kcps/MBq, respectively. Compared with the 39-ring scanner, the noise-equivalent counting rate of the 52-ring scanner was 60% higher for both the high-activity and the low-activity models. The recovery coefficient was consistent, irrespective of the number of detector rings. The coefficient of variation of the 52-ring scanner using a 3-min acquisition time was equivalent to that of the 39-ring scanner using a 4-min acquisition time. Conclusion: The image quality of the 52-ring scanner is superior to that of the 39-ring scanner. The acquisition time per bed position of the 52-ring system can be reduced by about 25% without compromising image quality. In addition, the number of bed positions required is 25% lower for the 52-ring system. Finally, the examination time required for a whole-body PET scan is considered to be reduced by about 40% if the 52-ring scanner is used.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalJournal of nuclear medicine technology
Volume42
Issue number2
DOIs
Publication statusPublished - Jun 2014

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Noise
Whole Body Imaging
Positron-Emission Tomography
lutetium orthosilicate

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Impact of time-of-flight PET/CT with a large axial field of view for reducing whole-body acquisition time. / Akamatsu, Go; Uba, Koji; Taniguchi, Takafumi; Mitsumoto, Katsuhiko; Narisue, Akihiro; Tsutsui, Yuji; Sasaki, Masayuki.

In: Journal of nuclear medicine technology, Vol. 42, No. 2, 06.2014, p. 101-104.

Research output: Contribution to journalArticle

Akamatsu, Go ; Uba, Koji ; Taniguchi, Takafumi ; Mitsumoto, Katsuhiko ; Narisue, Akihiro ; Tsutsui, Yuji ; Sasaki, Masayuki. / Impact of time-of-flight PET/CT with a large axial field of view for reducing whole-body acquisition time. In: Journal of nuclear medicine technology. 2014 ; Vol. 42, No. 2. pp. 101-104.
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abstract = "The aim of this study was to evaluate the imaging performance of 39- and 52-ring time-of-flight (TOF) PET/CT scanners. We also assessed the potential of reducing the scanning time using a 52-ring TOF PET/CT scanner. Methods: PET/CT scanners with 39- and 52-ring lutetium oxyorthosilicate detectors were evaluated. The axial fields of view were 16.2 and 21.6 cm, respectively. We used a National Electrical Manufacturers Association International Electrotechnical Commission body phantom filled with an 18F solution containing background activity of 5.31 and 2.65 kBq/mL for the studies. The sphere-to-background ratio was 4:1. The PET data were acquired for 10 min in 3-dimensional list mode and then reconstructed with both ordered-subsets reconstruction maximization and ordered-subsets reconstruction maximization plus point-spread function plus time-of-flight algorithms. PET images with different acquisition times were reconstructed (from 1 to 10 min). The image quality was physically assessed using the sensitivity, noise-equivalent counting rate, coefficient of variation of background activity, and relative recovery coefficient. Results: The total system sensitivities of the 39- and 52-ring scanners were 5.6 and 9.3 kcps/MBq, respectively. Compared with the 39-ring scanner, the noise-equivalent counting rate of the 52-ring scanner was 60{\%} higher for both the high-activity and the low-activity models. The recovery coefficient was consistent, irrespective of the number of detector rings. The coefficient of variation of the 52-ring scanner using a 3-min acquisition time was equivalent to that of the 39-ring scanner using a 4-min acquisition time. Conclusion: The image quality of the 52-ring scanner is superior to that of the 39-ring scanner. The acquisition time per bed position of the 52-ring system can be reduced by about 25{\%} without compromising image quality. In addition, the number of bed positions required is 25{\%} lower for the 52-ring system. Finally, the examination time required for a whole-body PET scan is considered to be reduced by about 40{\%} if the 52-ring scanner is used.",
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AU - Akamatsu, Go

AU - Uba, Koji

AU - Taniguchi, Takafumi

AU - Mitsumoto, Katsuhiko

AU - Narisue, Akihiro

AU - Tsutsui, Yuji

AU - Sasaki, Masayuki

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N2 - The aim of this study was to evaluate the imaging performance of 39- and 52-ring time-of-flight (TOF) PET/CT scanners. We also assessed the potential of reducing the scanning time using a 52-ring TOF PET/CT scanner. Methods: PET/CT scanners with 39- and 52-ring lutetium oxyorthosilicate detectors were evaluated. The axial fields of view were 16.2 and 21.6 cm, respectively. We used a National Electrical Manufacturers Association International Electrotechnical Commission body phantom filled with an 18F solution containing background activity of 5.31 and 2.65 kBq/mL for the studies. The sphere-to-background ratio was 4:1. The PET data were acquired for 10 min in 3-dimensional list mode and then reconstructed with both ordered-subsets reconstruction maximization and ordered-subsets reconstruction maximization plus point-spread function plus time-of-flight algorithms. PET images with different acquisition times were reconstructed (from 1 to 10 min). The image quality was physically assessed using the sensitivity, noise-equivalent counting rate, coefficient of variation of background activity, and relative recovery coefficient. Results: The total system sensitivities of the 39- and 52-ring scanners were 5.6 and 9.3 kcps/MBq, respectively. Compared with the 39-ring scanner, the noise-equivalent counting rate of the 52-ring scanner was 60% higher for both the high-activity and the low-activity models. The recovery coefficient was consistent, irrespective of the number of detector rings. The coefficient of variation of the 52-ring scanner using a 3-min acquisition time was equivalent to that of the 39-ring scanner using a 4-min acquisition time. Conclusion: The image quality of the 52-ring scanner is superior to that of the 39-ring scanner. The acquisition time per bed position of the 52-ring system can be reduced by about 25% without compromising image quality. In addition, the number of bed positions required is 25% lower for the 52-ring system. Finally, the examination time required for a whole-body PET scan is considered to be reduced by about 40% if the 52-ring scanner is used.

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