Impacts of acute imipramine treatment on plasma and brain amino acid metabolism in mice given graded levels of dietary chicken protein

Mao Nagasawa, Tatsuro Murakami, Shozo Tomonaga, Mikako Sato, Yoshihisa Takahata, Fumiki Morimatsu, Mitsuhiro Furuse

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Several studies have shown a relationship between depression and animal protein intake. To evaluate whether the difference of dietary chicken protein levels induces an antidepressant-like effect and potentiates acute antidepressant effects, three levels of dietary chicken protein were used as the representative animal protein with imipramine used as the antidepressant. In addition, the effects of dietary chicken protein on brain metabolism were evaluated. Open field test (OFT) and forced swimming test (FST) were conducted on the 27th and 28th days, respectively. OFT and FST were not influenced by both imipramine and dietary protein levels. However, characteristic effects of imipramine treatment on brain monoamine metabolism were observed in the cerebral cortex and hypothalamus. In addition, dietary protein significantly increased taurine and L-ornithine levels even though these amino acids were not contained in the diets. In conclusion, the metabolism of several amino acids in the plasma and brain were altered by dietary chicken protein.

Original languageEnglish
Pages (from-to)777-787
Number of pages11
JournalAnimal Science Journal
Volume83
Issue number12
DOIs
Publication statusPublished - Dec 2012

Fingerprint

Dietary Proteins
Imipramine
amino acid metabolism
antidepressants
Chickens
chickens
brain
Amino Acids
animal proteins
mice
Brain
Antidepressive Agents
dietary protein
proteins
testing
monoamines
metabolism
ornithine
cerebral cortex
taurine

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)

Cite this

Impacts of acute imipramine treatment on plasma and brain amino acid metabolism in mice given graded levels of dietary chicken protein. / Nagasawa, Mao; Murakami, Tatsuro; Tomonaga, Shozo; Sato, Mikako; Takahata, Yoshihisa; Morimatsu, Fumiki; Furuse, Mitsuhiro.

In: Animal Science Journal, Vol. 83, No. 12, 12.2012, p. 777-787.

Research output: Contribution to journalArticle

Nagasawa, Mao ; Murakami, Tatsuro ; Tomonaga, Shozo ; Sato, Mikako ; Takahata, Yoshihisa ; Morimatsu, Fumiki ; Furuse, Mitsuhiro. / Impacts of acute imipramine treatment on plasma and brain amino acid metabolism in mice given graded levels of dietary chicken protein. In: Animal Science Journal. 2012 ; Vol. 83, No. 12. pp. 777-787.
@article{3c7b53fcd5f546f094d81cbdee7e5d02,
title = "Impacts of acute imipramine treatment on plasma and brain amino acid metabolism in mice given graded levels of dietary chicken protein",
abstract = "Several studies have shown a relationship between depression and animal protein intake. To evaluate whether the difference of dietary chicken protein levels induces an antidepressant-like effect and potentiates acute antidepressant effects, three levels of dietary chicken protein were used as the representative animal protein with imipramine used as the antidepressant. In addition, the effects of dietary chicken protein on brain metabolism were evaluated. Open field test (OFT) and forced swimming test (FST) were conducted on the 27th and 28th days, respectively. OFT and FST were not influenced by both imipramine and dietary protein levels. However, characteristic effects of imipramine treatment on brain monoamine metabolism were observed in the cerebral cortex and hypothalamus. In addition, dietary protein significantly increased taurine and L-ornithine levels even though these amino acids were not contained in the diets. In conclusion, the metabolism of several amino acids in the plasma and brain were altered by dietary chicken protein.",
author = "Mao Nagasawa and Tatsuro Murakami and Shozo Tomonaga and Mikako Sato and Yoshihisa Takahata and Fumiki Morimatsu and Mitsuhiro Furuse",
year = "2012",
month = "12",
doi = "10.1111/j.1740-0929.2012.01025.x",
language = "English",
volume = "83",
pages = "777--787",
journal = "Animal Science Journal",
issn = "1344-3941",
publisher = "Wiley-Blackwell",
number = "12",

}

TY - JOUR

T1 - Impacts of acute imipramine treatment on plasma and brain amino acid metabolism in mice given graded levels of dietary chicken protein

AU - Nagasawa, Mao

AU - Murakami, Tatsuro

AU - Tomonaga, Shozo

AU - Sato, Mikako

AU - Takahata, Yoshihisa

AU - Morimatsu, Fumiki

AU - Furuse, Mitsuhiro

PY - 2012/12

Y1 - 2012/12

N2 - Several studies have shown a relationship between depression and animal protein intake. To evaluate whether the difference of dietary chicken protein levels induces an antidepressant-like effect and potentiates acute antidepressant effects, three levels of dietary chicken protein were used as the representative animal protein with imipramine used as the antidepressant. In addition, the effects of dietary chicken protein on brain metabolism were evaluated. Open field test (OFT) and forced swimming test (FST) were conducted on the 27th and 28th days, respectively. OFT and FST were not influenced by both imipramine and dietary protein levels. However, characteristic effects of imipramine treatment on brain monoamine metabolism were observed in the cerebral cortex and hypothalamus. In addition, dietary protein significantly increased taurine and L-ornithine levels even though these amino acids were not contained in the diets. In conclusion, the metabolism of several amino acids in the plasma and brain were altered by dietary chicken protein.

AB - Several studies have shown a relationship between depression and animal protein intake. To evaluate whether the difference of dietary chicken protein levels induces an antidepressant-like effect and potentiates acute antidepressant effects, three levels of dietary chicken protein were used as the representative animal protein with imipramine used as the antidepressant. In addition, the effects of dietary chicken protein on brain metabolism were evaluated. Open field test (OFT) and forced swimming test (FST) were conducted on the 27th and 28th days, respectively. OFT and FST were not influenced by both imipramine and dietary protein levels. However, characteristic effects of imipramine treatment on brain monoamine metabolism were observed in the cerebral cortex and hypothalamus. In addition, dietary protein significantly increased taurine and L-ornithine levels even though these amino acids were not contained in the diets. In conclusion, the metabolism of several amino acids in the plasma and brain were altered by dietary chicken protein.

UR - http://www.scopus.com/inward/record.url?scp=85027957468&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027957468&partnerID=8YFLogxK

U2 - 10.1111/j.1740-0929.2012.01025.x

DO - 10.1111/j.1740-0929.2012.01025.x

M3 - Article

C2 - 23216543

AN - SCOPUS:85027957468

VL - 83

SP - 777

EP - 787

JO - Animal Science Journal

JF - Animal Science Journal

SN - 1344-3941

IS - 12

ER -