Impaired erythrocyte deformability in patients with coronary risk factors

Significance of nonvalvular atrial fibrillation

Keita Odashiro, Toru Maruyama, Taku Yokoyama, Hisataka Nakamura, Mitsuhiro Fukata, Shioto Yasuda, Kazuyuki Saito, Takehiko Fujino, Koichi Akashi

Research output: Contribution to journalArticle

Abstract

Although coronary risk factors promote the formation of atherosclerotic plaque containing activated platelets and inflammatory leukocytes, and play a pivotal role in the development of coronary artery diseases (CAD), the hemorheological effects of these risk factors on circulating intact erythrocytes, a major component of whole blood cells, are poorly understood. Therefore, this study aimed to quantify erythrocyte deformability in patients with coronary risk factors, and enrolled 320 consecutive cardiac outpatients including 33 patients with nonvalvular atrial fibrillation (AF). Patients,with acute coronary syndrome or valvular AF,were excluded. Demographic variables obtained by medical records were correlated with erythrocyte deformability investigated by our highly sensitive and reproducible filtration technique. Among demographic variables, triglyceride (p = 0.004), HbA1c (p = 0.014) and body weight (p = 0.020) showed significant inverse correlation to the erythrocyte deformability. This deformability was not associated with types of CAD (old myocardial infarction vs. stable angina) or modality of treatment (percutaneous intervention vs. coronary artery bypass grafting). Unexpectedly, stepwise multiple regression analysis demonstrated that nonvalvular AF was the most significant contributor to the impaired erythrocyte deformability (p = 0.002). Hypertension and dyslipidemia are more prevalent in the AF patients (p < 0.001), and the erythrocyte deformability was found to be impaired synergistically and significantly (p < 0.001) during the stepwise accumulation of the coronary risk factors in addition to AF. In conclusion coronary risk factors synergistically impair the erythrocyte deformability, which may play an important role in critically stenotic coronary arteries. Since the impairment of intact erythrocyte deformability is mostly associated with nonvalvular AF, this common arrhythmia may reflect the coronary risk accumulation.

Original languageEnglish
Pages (from-to)6-12
Number of pages7
JournalJournal of Atrial Fibrillation
Volume6
Issue number3
Publication statusPublished - Oct 1 2013

Fingerprint

Erythrocyte Deformability
Atrial Fibrillation
Demography
Stable Angina
Atherosclerotic Plaques
Acute Coronary Syndrome
Dyslipidemias
Coronary Artery Bypass
Medical Records
Cardiac Arrhythmias
Coronary Artery Disease
Blood Cells
Coronary Vessels
Triglycerides
Leukocytes
Outpatients
Blood Platelets
Erythrocytes
Body Weight
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Impaired erythrocyte deformability in patients with coronary risk factors : Significance of nonvalvular atrial fibrillation. / Odashiro, Keita; Maruyama, Toru; Yokoyama, Taku; Nakamura, Hisataka; Fukata, Mitsuhiro; Yasuda, Shioto; Saito, Kazuyuki; Fujino, Takehiko; Akashi, Koichi.

In: Journal of Atrial Fibrillation, Vol. 6, No. 3, 01.10.2013, p. 6-12.

Research output: Contribution to journalArticle

@article{75aeb71e1833469dae7a74efbaa2c75a,
title = "Impaired erythrocyte deformability in patients with coronary risk factors: Significance of nonvalvular atrial fibrillation",
abstract = "Although coronary risk factors promote the formation of atherosclerotic plaque containing activated platelets and inflammatory leukocytes, and play a pivotal role in the development of coronary artery diseases (CAD), the hemorheological effects of these risk factors on circulating intact erythrocytes, a major component of whole blood cells, are poorly understood. Therefore, this study aimed to quantify erythrocyte deformability in patients with coronary risk factors, and enrolled 320 consecutive cardiac outpatients including 33 patients with nonvalvular atrial fibrillation (AF). Patients,with acute coronary syndrome or valvular AF,were excluded. Demographic variables obtained by medical records were correlated with erythrocyte deformability investigated by our highly sensitive and reproducible filtration technique. Among demographic variables, triglyceride (p = 0.004), HbA1c (p = 0.014) and body weight (p = 0.020) showed significant inverse correlation to the erythrocyte deformability. This deformability was not associated with types of CAD (old myocardial infarction vs. stable angina) or modality of treatment (percutaneous intervention vs. coronary artery bypass grafting). Unexpectedly, stepwise multiple regression analysis demonstrated that nonvalvular AF was the most significant contributor to the impaired erythrocyte deformability (p = 0.002). Hypertension and dyslipidemia are more prevalent in the AF patients (p < 0.001), and the erythrocyte deformability was found to be impaired synergistically and significantly (p < 0.001) during the stepwise accumulation of the coronary risk factors in addition to AF. In conclusion coronary risk factors synergistically impair the erythrocyte deformability, which may play an important role in critically stenotic coronary arteries. Since the impairment of intact erythrocyte deformability is mostly associated with nonvalvular AF, this common arrhythmia may reflect the coronary risk accumulation.",
author = "Keita Odashiro and Toru Maruyama and Taku Yokoyama and Hisataka Nakamura and Mitsuhiro Fukata and Shioto Yasuda and Kazuyuki Saito and Takehiko Fujino and Koichi Akashi",
year = "2013",
month = "10",
day = "1",
language = "English",
volume = "6",
pages = "6--12",
journal = "Journal of Atrial Fibrillation",
issn = "1941-6911",
publisher = "Cardiofront, Inc.",
number = "3",

}

TY - JOUR

T1 - Impaired erythrocyte deformability in patients with coronary risk factors

T2 - Significance of nonvalvular atrial fibrillation

AU - Odashiro, Keita

AU - Maruyama, Toru

AU - Yokoyama, Taku

AU - Nakamura, Hisataka

AU - Fukata, Mitsuhiro

AU - Yasuda, Shioto

AU - Saito, Kazuyuki

AU - Fujino, Takehiko

AU - Akashi, Koichi

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Although coronary risk factors promote the formation of atherosclerotic plaque containing activated platelets and inflammatory leukocytes, and play a pivotal role in the development of coronary artery diseases (CAD), the hemorheological effects of these risk factors on circulating intact erythrocytes, a major component of whole blood cells, are poorly understood. Therefore, this study aimed to quantify erythrocyte deformability in patients with coronary risk factors, and enrolled 320 consecutive cardiac outpatients including 33 patients with nonvalvular atrial fibrillation (AF). Patients,with acute coronary syndrome or valvular AF,were excluded. Demographic variables obtained by medical records were correlated with erythrocyte deformability investigated by our highly sensitive and reproducible filtration technique. Among demographic variables, triglyceride (p = 0.004), HbA1c (p = 0.014) and body weight (p = 0.020) showed significant inverse correlation to the erythrocyte deformability. This deformability was not associated with types of CAD (old myocardial infarction vs. stable angina) or modality of treatment (percutaneous intervention vs. coronary artery bypass grafting). Unexpectedly, stepwise multiple regression analysis demonstrated that nonvalvular AF was the most significant contributor to the impaired erythrocyte deformability (p = 0.002). Hypertension and dyslipidemia are more prevalent in the AF patients (p < 0.001), and the erythrocyte deformability was found to be impaired synergistically and significantly (p < 0.001) during the stepwise accumulation of the coronary risk factors in addition to AF. In conclusion coronary risk factors synergistically impair the erythrocyte deformability, which may play an important role in critically stenotic coronary arteries. Since the impairment of intact erythrocyte deformability is mostly associated with nonvalvular AF, this common arrhythmia may reflect the coronary risk accumulation.

AB - Although coronary risk factors promote the formation of atherosclerotic plaque containing activated platelets and inflammatory leukocytes, and play a pivotal role in the development of coronary artery diseases (CAD), the hemorheological effects of these risk factors on circulating intact erythrocytes, a major component of whole blood cells, are poorly understood. Therefore, this study aimed to quantify erythrocyte deformability in patients with coronary risk factors, and enrolled 320 consecutive cardiac outpatients including 33 patients with nonvalvular atrial fibrillation (AF). Patients,with acute coronary syndrome or valvular AF,were excluded. Demographic variables obtained by medical records were correlated with erythrocyte deformability investigated by our highly sensitive and reproducible filtration technique. Among demographic variables, triglyceride (p = 0.004), HbA1c (p = 0.014) and body weight (p = 0.020) showed significant inverse correlation to the erythrocyte deformability. This deformability was not associated with types of CAD (old myocardial infarction vs. stable angina) or modality of treatment (percutaneous intervention vs. coronary artery bypass grafting). Unexpectedly, stepwise multiple regression analysis demonstrated that nonvalvular AF was the most significant contributor to the impaired erythrocyte deformability (p = 0.002). Hypertension and dyslipidemia are more prevalent in the AF patients (p < 0.001), and the erythrocyte deformability was found to be impaired synergistically and significantly (p < 0.001) during the stepwise accumulation of the coronary risk factors in addition to AF. In conclusion coronary risk factors synergistically impair the erythrocyte deformability, which may play an important role in critically stenotic coronary arteries. Since the impairment of intact erythrocyte deformability is mostly associated with nonvalvular AF, this common arrhythmia may reflect the coronary risk accumulation.

UR - http://www.scopus.com/inward/record.url?scp=84892881048&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892881048&partnerID=8YFLogxK

M3 - Article

VL - 6

SP - 6

EP - 12

JO - Journal of Atrial Fibrillation

JF - Journal of Atrial Fibrillation

SN - 1941-6911

IS - 3

ER -