Impaired forearm vasodilatation by acetylcholine in patients with hypertension

Megumu Yoshida, Tsutomu Imaizumi, Shin ichi Ando, Yoshitaka Hirooka, Seiki Harada, Akira Takeshita

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The aim of this study was to examine if vasodilatory responses to acetylcholine or sodium nitroprusside are altered in subjects with essential hypertension. In patients with essential hypertension (mean BP; 121±4 mmHg, n=14) and age-matched control subjects (mean BP; 88±3 mmHg, n=10), the forearm vasodilatory responses to acetylcholine and sodium nitroprusside were examined. The brachial artery was cannulated with a cannula through which drugs were locally infused. During the drug infusions, forearm blood flow was continuously measured using plethysmography. Basal forearm vascular resistance was higher in patients with essential hypertension than in control subjects (27.5±3.8 vs 13.8±1.7 units, P<0.01). The increases in forearm blood flow or decreases in forearm vascular resistance in response to the infusions of acetylcholine were smaller in patients with essential hypertension than in control subjects (P<0.01). However, the increases in forearm blood flow or decreases in forearm vascular resistance in response to the infusions of sodium nitroprusside were similar for the 2 groups. These results may suggest that the endothelium-dependent vasodilatory response to acetylcholine in the forearm resistance arteries is impaired in patients with essential hypertension.

Original languageEnglish
Pages (from-to)218-223
Number of pages6
JournalHeart and Vessels
Volume6
Issue number4
DOIs
Publication statusPublished - Dec 1 1991

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Forearm
Vasodilation
Acetylcholine
Hypertension
Nitroprusside
Vascular Resistance
Plethysmography
Brachial Artery
Pharmaceutical Preparations
Endothelium
Arteries
Essential Hypertension

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Yoshida, M., Imaizumi, T., Ando, S. I., Hirooka, Y., Harada, S., & Takeshita, A. (1991). Impaired forearm vasodilatation by acetylcholine in patients with hypertension. Heart and Vessels, 6(4), 218-223. https://doi.org/10.1007/BF02125100

Impaired forearm vasodilatation by acetylcholine in patients with hypertension. / Yoshida, Megumu; Imaizumi, Tsutomu; Ando, Shin ichi; Hirooka, Yoshitaka; Harada, Seiki; Takeshita, Akira.

In: Heart and Vessels, Vol. 6, No. 4, 01.12.1991, p. 218-223.

Research output: Contribution to journalArticle

Yoshida, M, Imaizumi, T, Ando, SI, Hirooka, Y, Harada, S & Takeshita, A 1991, 'Impaired forearm vasodilatation by acetylcholine in patients with hypertension', Heart and Vessels, vol. 6, no. 4, pp. 218-223. https://doi.org/10.1007/BF02125100
Yoshida M, Imaizumi T, Ando SI, Hirooka Y, Harada S, Takeshita A. Impaired forearm vasodilatation by acetylcholine in patients with hypertension. Heart and Vessels. 1991 Dec 1;6(4):218-223. https://doi.org/10.1007/BF02125100
Yoshida, Megumu ; Imaizumi, Tsutomu ; Ando, Shin ichi ; Hirooka, Yoshitaka ; Harada, Seiki ; Takeshita, Akira. / Impaired forearm vasodilatation by acetylcholine in patients with hypertension. In: Heart and Vessels. 1991 ; Vol. 6, No. 4. pp. 218-223.
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