Impaired glucose tolerance and insulin resistance in chronic calcifying pancreatitis

K. Ogoshi, I. Nakano, T. Ito, T. Miyahara, S. Koyanagi, Y. Migita, N. Sekiguchi, F. Ueda, H. Nawata

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We investigated pancreatic endocrine function, exocrine function and insulin resistance in 9 subjects with chronic calcifying pancreatitis (CCP). Insulin and glucagon secretory function were reduced in most of the patients, and pancreatic exocrine function was disturbed in all 9. Insulin resistance was evaluated using a euglycemic hyperinsulinemic clamp technique. Most of the patients had marked insulin resistance. The correlation between glucagon secretory function and insulin resistance was statistically significant. The results suggested that the reductions in insulin secretion and insulin resistance were observed in the early stage of impaired glucose tolerance associated with chronic pancreatitis and that the insulin resistance diminished together with the development of A cell dysfunction.

Original languageEnglish
Pages (from-to)651-656
Number of pages6
JournalJournal of the Japan Diabetes Society
Volume42
Issue number8
Publication statusPublished - 1999

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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