TY - JOUR
T1 - Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice
AU - Egashira, Nobuaki
AU - Tanoue, Akito
AU - Matsuda, Tomomi
AU - Koushi, Emi
AU - Harada, Satoko
AU - Takano, Yukio
AU - Tsujimoto, Gozoh
AU - Mishima, Kenichi
AU - Iwasaki, Katsunori
AU - Fujiwara, Michihiro
N1 - Funding Information:
This study was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (No. 18591318).
PY - 2007/3/12
Y1 - 2007/3/12
N2 - The arginine vasopressin (AVP) system plays an important role in social behavior. Autism, with its hallmark disturbances in social behavior, has been associated with the V1a receptor (V1aR) gene. Furthermore, impairments of social function are often observed in symptoms of schizophrenia. Subchronic phencyclidine (PCP) produces behaviors relating to certain aspects of schizophrenic symptoms such as impairing social interaction in animals and it reduces the density of V1aR binding sites in several brain regions. Here, we report that V1aR knockout (KO) mice exhibited impairment of social behavior in a social interaction test, and showed reduced anxiety-related behavior in elevated plus-maze and marble-burying behavior tests. Given the current findings, the V1aR may be involved in the regulation of social interaction, and V1aR KO mice could be used as an animal model of psychiatric disorders associated with social behavior deficits, such as autism and schizophrenia.
AB - The arginine vasopressin (AVP) system plays an important role in social behavior. Autism, with its hallmark disturbances in social behavior, has been associated with the V1a receptor (V1aR) gene. Furthermore, impairments of social function are often observed in symptoms of schizophrenia. Subchronic phencyclidine (PCP) produces behaviors relating to certain aspects of schizophrenic symptoms such as impairing social interaction in animals and it reduces the density of V1aR binding sites in several brain regions. Here, we report that V1aR knockout (KO) mice exhibited impairment of social behavior in a social interaction test, and showed reduced anxiety-related behavior in elevated plus-maze and marble-burying behavior tests. Given the current findings, the V1aR may be involved in the regulation of social interaction, and V1aR KO mice could be used as an animal model of psychiatric disorders associated with social behavior deficits, such as autism and schizophrenia.
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U2 - 10.1016/j.bbr.2006.12.009
DO - 10.1016/j.bbr.2006.12.009
M3 - Article
C2 - 17227684
AN - SCOPUS:33846951809
SN - 0166-4328
VL - 178
SP - 123
EP - 127
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -