Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice

Nobuaki Egashira, Akito Tanoue, Tomomi Matsuda, Emi Koushi, Satoko Harada, Yukio Takano, Gozoh Tsujimoto, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara

Research output: Contribution to journalArticlepeer-review

117 Citations (Scopus)

Abstract

The arginine vasopressin (AVP) system plays an important role in social behavior. Autism, with its hallmark disturbances in social behavior, has been associated with the V1a receptor (V1aR) gene. Furthermore, impairments of social function are often observed in symptoms of schizophrenia. Subchronic phencyclidine (PCP) produces behaviors relating to certain aspects of schizophrenic symptoms such as impairing social interaction in animals and it reduces the density of V1aR binding sites in several brain regions. Here, we report that V1aR knockout (KO) mice exhibited impairment of social behavior in a social interaction test, and showed reduced anxiety-related behavior in elevated plus-maze and marble-burying behavior tests. Given the current findings, the V1aR may be involved in the regulation of social interaction, and V1aR KO mice could be used as an animal model of psychiatric disorders associated with social behavior deficits, such as autism and schizophrenia.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalBehavioural Brain Research
Volume178
Issue number1
DOIs
Publication statusPublished - Mar 12 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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