Impaired Tumor Phenotypes in Class II Major Histocompatibility Complex Antigen-Inducible Cells Originated from Human Lung Adenocarcinoma

S. Kawamoto, Y. Inoue, Y. Shinozaki, Yoshinori Katakura, Hirofumi Tachibana, S. Shirahata, H. Murakami

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The class II major histocompatibility complex (MHC) antigens play important roles in T cell activation and are thought to be involved in tumor development. Using anti-class II antibodies with interferon gamma (IFN-γ), we have here selected class II MHC antigen positive cancer cells from the human lung adenocarcinoma cell line A549, which is originally negative (>95%) for the antigens. A part of the class II antigen-positive cells presented a flat morphology, which was not observed in the parental A549 cells. Class II antigen expression in these flat cells was IFN-γ, inducible; there was a correlation between the inducibility and phenotypic changes. A class II antigen-inducible flat subline restored the ability of contact inhibition and anchorage-dependent growth as well as lost tumorigenicity in athymic mice.

Original languageEnglish
Pages (from-to)280-285
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume215
Issue number1
DOIs
Publication statusPublished - Oct 4 1995

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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