Impairment of spatial learning and hippocampal synaptic potentiation in c-kit mutant rats

Toshihiko Katafuchi, Ai Jun Li, Seiichi Hirota, Yukihiko Kitamura, Tetsuro Hori

Research output: Contribution to journalArticle

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Abstract

The c-kit receptor tyrosine kinase encoded by the white-spotting (W) gene is highly expressed in rat hippocampal CA1-CA4 regions. We found an impaired spatial learning and memory in homozygous c-kit (Ws/Ws) mutant rats that have a 12-base deletion in the tyrosine kinase domain of the c-kit gene and a very low kinase activity. Electrophysiological studies in hippocampal slices revealed that the long-term potentiation (LTP) induced by the tetanic stimulation (100 Hz, 1 sec) in the mossy fiber (MF)-CA3 pathway, but not in the Schaffer collaterals/commissural-CA1 pathway, was significantly reduced in c-kit mutants compared with wild-type (+/+) rats. The paired-pulse facilitation (PPF) was measured before the tetanus and after the establishment of the LTP in each slice. The initial PPF in the MF-CA3 pathway positively correlated with the amplitude of the LTP in the wild-type rats but not in the c-kit mutant rats. Furthermore, they failed to show the normal characteristics observed in the MF-CA3 pathway of +/+ rats; that is, the negative correlation between the initial PPF and the changes in PPF measured after the LTP. These findings suggest an involvement of SCF/c-kit signaling in hippocampal synaptic potentiation and spatial learning and memory.

Original languageEnglish
Pages (from-to)383-392
Number of pages10
JournalLearning and Memory
Volume7
Issue number6
DOIs
Publication statusPublished - Dec 1 2000

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Long-Term Potentiation
Protein-Tyrosine Kinases
Proto-Oncogene Proteins c-kit
Hippocampal CA1 Region
Metrorrhagia
Dentate Gyrus
Tetanus
Genes
Spatial Learning
Hippocampus
Phosphotransferases
Spatial Memory

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Impairment of spatial learning and hippocampal synaptic potentiation in c-kit mutant rats. / Katafuchi, Toshihiko; Li, Ai Jun; Hirota, Seiichi; Kitamura, Yukihiko; Hori, Tetsuro.

In: Learning and Memory, Vol. 7, No. 6, 01.12.2000, p. 383-392.

Research output: Contribution to journalArticle

Katafuchi, T, Li, AJ, Hirota, S, Kitamura, Y & Hori, T 2000, 'Impairment of spatial learning and hippocampal synaptic potentiation in c-kit mutant rats', Learning and Memory, vol. 7, no. 6, pp. 383-392. https://doi.org/10.1101/lm.33900
Katafuchi, Toshihiko ; Li, Ai Jun ; Hirota, Seiichi ; Kitamura, Yukihiko ; Hori, Tetsuro. / Impairment of spatial learning and hippocampal synaptic potentiation in c-kit mutant rats. In: Learning and Memory. 2000 ; Vol. 7, No. 6. pp. 383-392.
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