Impairment of spatial short-term memory following acute administration of the NMDA receptor antagonist in heterozygous rolling Nagoya mice carrying the CaV2.1α1 mutation

Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Heterozygous rolling Nagoya (rol/+) mice carrying CaV2.1α1 mutation demonstrated normal behavior in Y maze test. Similar spontaneous alternation patterns were noted in wild-type and rol/+ mice injected with N-methyl-d-aspartate (NMDA; 0-50mg/kg, sc). Systemic injection of NMDA receptor blocker (MK-801; 0.05mg/kg, ip) or intrahippocampal injection of MK-801 (0.5μg/side), which had no effect in wild-type controls, decreased spatial cognition in rol/+ mice. These results indicate that CaV2.1α1 mutation probably through decrease in Ca2+ influx lowers the threshold for learning impairment. The combination subthreshold pharmacological and genetic approach is useful to study functional pathways in neuronal circuits.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalBehavioural Brain Research
Volume213
Issue number1
DOIs
Publication statusPublished - Nov 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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