Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer

Yoshifumi Iwagami, Hidetoshi Eguchi, Hiroshi Wada, Yoshito Tomimaru, Naoki Hama, Koichi Kawamoto, Shogo Kobayashi, Masaki Mori, Yuichiro Doki, Hiroaki Nagano

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Abstract

Purpose: The aim of this study was to determine the utility of the peritoneal lavage cytology findings in predicting the clinical outcomes of resectable left-sided pancreatic cancer.

Results: Five patients (12.8 %) had malignant cells in the cytology samples (positive cytology). This occurred more frequently in patients with vascular invasion (P = 0.008). Positive cytology was significantly associated with lower overall (P = 0.0007) and recurrent-free (P < 0.0001) survival rates. Positive cytology was an independent prognostic factor for recurrence (P = 0.022); it was closely associated with local recurrence, peritoneal recurrence and distant metastasis.

Methods: Peritoneal lavage samples were collected from 39 consecutive patients who underwent surgery for left-sided pancreatic cancer between January 2000 and December 2010. We analyzed the correlations between the peritoneal lavage cytology findings and the clinical outcomes.

Conclusion: Surgeons should carefully consider the intraoperative diagnosis of peritoneal lavage cytology in patients with resectable left-sided pancreatic cancers, because patients with positive cytology are likely to experience recurrence.

Original languageEnglish
Pages (from-to)444-450
Number of pages7
JournalSurgery today
Volume45
Issue number4
DOIs
Publication statusPublished - Jan 1 2015

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Peritoneal Lavage
Pancreatic Neoplasms
Cell Biology
Recurrence
Blood Vessels
Survival Rate
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Iwagami, Y., Eguchi, H., Wada, H., Tomimaru, Y., Hama, N., Kawamoto, K., ... Nagano, H. (2015). Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer. Surgery today, 45(4), 444-450. https://doi.org/10.1007/s00595-014-0964-7

Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer. / Iwagami, Yoshifumi; Eguchi, Hidetoshi; Wada, Hiroshi; Tomimaru, Yoshito; Hama, Naoki; Kawamoto, Koichi; Kobayashi, Shogo; Mori, Masaki; Doki, Yuichiro; Nagano, Hiroaki.

In: Surgery today, Vol. 45, No. 4, 01.01.2015, p. 444-450.

Research output: Contribution to journalArticle

Iwagami, Y, Eguchi, H, Wada, H, Tomimaru, Y, Hama, N, Kawamoto, K, Kobayashi, S, Mori, M, Doki, Y & Nagano, H 2015, 'Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer', Surgery today, vol. 45, no. 4, pp. 444-450. https://doi.org/10.1007/s00595-014-0964-7
Iwagami Y, Eguchi H, Wada H, Tomimaru Y, Hama N, Kawamoto K et al. Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer. Surgery today. 2015 Jan 1;45(4):444-450. https://doi.org/10.1007/s00595-014-0964-7
Iwagami, Yoshifumi ; Eguchi, Hidetoshi ; Wada, Hiroshi ; Tomimaru, Yoshito ; Hama, Naoki ; Kawamoto, Koichi ; Kobayashi, Shogo ; Mori, Masaki ; Doki, Yuichiro ; Nagano, Hiroaki. / Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer. In: Surgery today. 2015 ; Vol. 45, No. 4. pp. 444-450.
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AU - Kawamoto, Koichi

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N2 - Purpose: The aim of this study was to determine the utility of the peritoneal lavage cytology findings in predicting the clinical outcomes of resectable left-sided pancreatic cancer.Results: Five patients (12.8 %) had malignant cells in the cytology samples (positive cytology). This occurred more frequently in patients with vascular invasion (P = 0.008). Positive cytology was significantly associated with lower overall (P = 0.0007) and recurrent-free (P < 0.0001) survival rates. Positive cytology was an independent prognostic factor for recurrence (P = 0.022); it was closely associated with local recurrence, peritoneal recurrence and distant metastasis.Methods: Peritoneal lavage samples were collected from 39 consecutive patients who underwent surgery for left-sided pancreatic cancer between January 2000 and December 2010. We analyzed the correlations between the peritoneal lavage cytology findings and the clinical outcomes.Conclusion: Surgeons should carefully consider the intraoperative diagnosis of peritoneal lavage cytology in patients with resectable left-sided pancreatic cancers, because patients with positive cytology are likely to experience recurrence.

AB - Purpose: The aim of this study was to determine the utility of the peritoneal lavage cytology findings in predicting the clinical outcomes of resectable left-sided pancreatic cancer.Results: Five patients (12.8 %) had malignant cells in the cytology samples (positive cytology). This occurred more frequently in patients with vascular invasion (P = 0.008). Positive cytology was significantly associated with lower overall (P = 0.0007) and recurrent-free (P < 0.0001) survival rates. Positive cytology was an independent prognostic factor for recurrence (P = 0.022); it was closely associated with local recurrence, peritoneal recurrence and distant metastasis.Methods: Peritoneal lavage samples were collected from 39 consecutive patients who underwent surgery for left-sided pancreatic cancer between January 2000 and December 2010. We analyzed the correlations between the peritoneal lavage cytology findings and the clinical outcomes.Conclusion: Surgeons should carefully consider the intraoperative diagnosis of peritoneal lavage cytology in patients with resectable left-sided pancreatic cancers, because patients with positive cytology are likely to experience recurrence.

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