Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer

Yoshifumi Iwagami, Hidetoshi Eguchi, Hiroshi Wada, Yoshito Tomimaru, Naoki Hama, Koichi Kawamoto, Shogo Kobayashi, Masaki Mori, Yuichiro Doki, Hiroaki Nagano

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14 Citations (Scopus)

Abstract

Purpose: The aim of this study was to determine the utility of the peritoneal lavage cytology findings in predicting the clinical outcomes of resectable left-sided pancreatic cancer.

Results: Five patients (12.8 %) had malignant cells in the cytology samples (positive cytology). This occurred more frequently in patients with vascular invasion (P = 0.008). Positive cytology was significantly associated with lower overall (P = 0.0007) and recurrent-free (P < 0.0001) survival rates. Positive cytology was an independent prognostic factor for recurrence (P = 0.022); it was closely associated with local recurrence, peritoneal recurrence and distant metastasis.

Methods: Peritoneal lavage samples were collected from 39 consecutive patients who underwent surgery for left-sided pancreatic cancer between January 2000 and December 2010. We analyzed the correlations between the peritoneal lavage cytology findings and the clinical outcomes.

Conclusion: Surgeons should carefully consider the intraoperative diagnosis of peritoneal lavage cytology in patients with resectable left-sided pancreatic cancers, because patients with positive cytology are likely to experience recurrence.

Original languageEnglish
Pages (from-to)444-450
Number of pages7
JournalSurgery today
Volume45
Issue number4
DOIs
Publication statusPublished - Jan 1 2015

All Science Journal Classification (ASJC) codes

  • Surgery

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    Iwagami, Y., Eguchi, H., Wada, H., Tomimaru, Y., Hama, N., Kawamoto, K., Kobayashi, S., Mori, M., Doki, Y., & Nagano, H. (2015). Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer. Surgery today, 45(4), 444-450. https://doi.org/10.1007/s00595-014-0964-7