Implications of tryptophan photoproduct FICZ in oxidative stress and terminal differentiation of keratinocytes

Masutaka Furue, Hiroshi Uchi, Chikage Mitoma, Akiko Hashimoto-Hachiya, Yuka Tanaka, Takamichi Ito, Gaku Tsuji

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Ultraviolet B (UVB) irradiation activates aryl hydrocarbon receptor (AHR), generates reactive oxygen species (ROS) and mediates photocarcinogenesis and photoaging. 6-Formylindolo[3,2-b]carbazole (FICZ) is a tryptophan photoproduct generated by UVB exposure. FICZ exhibits similar biological effects to UVB, including AHR ligation and ROS production. FICZ also acts as a potent photosensitizer for UVA and the production of ROS is synergistically augmented in the simultaneous presence of FICZ and UVA. In contrast, FICZ upregulates the expression of terminal differentiation molecules such as filaggrin and loricrin via AHR. In parallel with this, the administration of FICZ inhibits skin inflammation in a murine psoriasis and dermatitis model. In this article, we summarize the harmful and beneficial aspects of FICZ in skin pathology.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalGiornale Italiano di Dermatologia e Venereologia
Volume154
Issue number1
DOIs
Publication statusPublished - Feb 2019

All Science Journal Classification (ASJC) codes

  • Dermatology

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