Important role of β 1-integrin in fucoidan-induced apoptosis via caspase-8 activation

Yumi Yamasaki, Masao Yamasaki, Hirofumi Tachibana, Koji Yamada

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Fucoidan induces apoptosis by activating caspase-8 in human MCF-7 breast cancer cells, but the detailed mechanism for this is not understood. We demonstrate here that fucoidan interacted with the cell surface, and silencing the β 1-integrin gene expression inhibited fucoidan-induced apoptosis accompanied by caspase-8 activation. Fucoidan induced formation of the β 1-integrin-caspase-8 complex. These data indicate that β 1-integrin is an important factor for the cell-surface binding of fucoidan and plays an important role in fucoidan-induced apoptosis. Fucoidan also induced recruitment of caspase-8 to the β 1-integrin intracellular domain, cleaved it into the activated protein by direct combination with β 1-integrin, and induced apoptosis via the caspase cascade in MCF-7 cells.

Original languageEnglish
Pages (from-to)1163-1168
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume76
Issue number6
DOIs
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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