Imprinting and looping: Epigenetic marks control interactions between regulatory elements

Yuzuru Kato, Hiroyuki Sasaki

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)

Abstract

Gene regulation involves various cis-regulatory elements that can act at a distance. They may physically interact each other or with their target genes to exert their effects. Such interactions are beginning to be uncovered in the imprinted lgf2/H19 domain. The differentially methylated regions (DMRs), containing insulators, silencers and activators, were shown to have physical contacts between them. The interactions were changeable depending on their epigenetic state, presumably enabling lgf2 to move between an active and a silent chromatin domain. The study gives us a novel view on how regulatory elements influence gene expression and how epigenetic modifications modulate their long-range effects.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalBioEssays
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 1 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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