Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications

Akatsuki Saito, Masako Nomaguchi, Sayuki Iijima, Ayumu Kuroishi, Tomoyuki Yoshida, Young Jung Lee, Toshiyuki Hayakawa, Ken Kono, Emi E. Nakayama, Tatsuo Shioda, Yasuhiro Yasutomi, Akio Adachi, Tetsuro Matano, Hirofumi Akari

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Human immunodeficiency virus type 1 (HIV-1) hardly replicates in Old World monkeys. Recently, a mutant HIV-1 clone, NL-DT5R, in which a small part of gag and the entire vif gene are replaced with SIVmac239-derived ones, was shown to be able to replicate in pigtail monkeys but not in rhesus monkeys (RM). In the present study, we found that a modified monkey-tropic HIV-1 (HIV-1mt), MN4-5S, acquired the ability to replicate efficiently in cynomolgus monkeys as compared with the NL-DT5R, while neither NL-DT5R nor MN4-5S replicated in RM cells. These results suggest that multiple determinants may be involved in the restriction of HIV-1 replication in macaques, depending on the species of macaques. The new HIV-1mt clone will be useful for studying molecular mechanisms by which anti-viral host factors regulate HIV-1 replication in macaques.

Original languageEnglish
Pages (from-to)58-64
Number of pages7
JournalMicrobes and Infection
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Infectious Diseases

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