Improved isotopic deuterium labeling at the diastereotopic methyl group of leucine: A synthetic route to (4S)- and (4R)-[5-2H 1]leucine

Noriaki Yamauchi; Satoshi Endoh

doi:10.1271/bbb.70.276

Improved isotopic deuterium labeling at the diastereotopic methyl group of leucine: A synthetic route to (4S)- and (4R)-[5-²H ₁]leucine

Noriaki Yamauchi, Satoshi Endoh

Material Science of Solar Planets

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Two isotopomers of deuterium-labeled leucine in the diastereotopic methyl group were synthesized from inexpensively available (R)- and (S)-citronellol in a more convenient way than by previous methods.

Original language	English
Pages (from-to)	276-278
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	70
Issue number	1
DOIs	https://doi.org/10.1271/bbb.70.276
Publication status	Published - 2006

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.70.276

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title = "Improved isotopic deuterium labeling at the diastereotopic methyl group of leucine: A synthetic route to (4S)- and (4R)-[5-2H 1]leucine",

abstract = "Two isotopomers of deuterium-labeled leucine in the diastereotopic methyl group were synthesized from inexpensively available (R)- and (S)-citronellol in a more convenient way than by previous methods.",

author = "Noriaki Yamauchi and Satoshi Endoh",

note = "Funding Information: We thank Prof. Katsuki and Assoc. Prof. Irie (Kyushu University) for measuring the optical rotation. This study was supported in part by grant-aid from the Kurita Water and Environmental Foundation.",

year = "2006",

doi = "10.1271/bbb.70.276",

language = "English",

volume = "70",

pages = "276--278",

journal = "Bioscience, Biotechnology and Biochemistry",

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T2 - A synthetic route to (4S)- and (4R)-[5-2H 1]leucine

AU - Yamauchi, Noriaki

AU - Endoh, Satoshi

N1 - Funding Information: We thank Prof. Katsuki and Assoc. Prof. Irie (Kyushu University) for measuring the optical rotation. This study was supported in part by grant-aid from the Kurita Water and Environmental Foundation.

PY - 2006

Y1 - 2006

N2 - Two isotopomers of deuterium-labeled leucine in the diastereotopic methyl group were synthesized from inexpensively available (R)- and (S)-citronellol in a more convenient way than by previous methods.

AB - Two isotopomers of deuterium-labeled leucine in the diastereotopic methyl group were synthesized from inexpensively available (R)- and (S)-citronellol in a more convenient way than by previous methods.

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AN - SCOPUS:31444448586

SN - 0916-8451

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EP - 278

JO - Bioscience, Biotechnology and Biochemistry

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ER -

Improved isotopic deuterium labeling at the diastereotopic methyl group of leucine: A synthetic route to (4S)- and (4R)-[5-²H ₁]leucine

Abstract

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