Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens

Kazutoshi Aoyama, Motoko Koyama, Ken Ichi Matsuoka, Daigo Hashimoto, Tatsuo Ichinohe, Mine Harada, Koichi Akashi, Mitsune Tanimoto, Takanori Teshima

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Exposure of offspring to noninherited maternal antigens (NIMAs) during pregnancy may have an impact on transplantations performed later in life. Using a mouse model, we recently showed that bone marrow transplantation (BMT) from NIMA-exposed offspring to the mother led to a reduction of graft-versus-host disease (GVHD). Since offspring can also be exposed to NIMAs by breastfeeding after birth, we tested whether breast milk could mediate the tolerogenic NIMA effect. We found that oral exposure to NI-MAs by breastfeeding alone was sufficient to reduce GVHD, and that in utero exposure to NIMAs is required for maximum reduction of GVHD. The tolerogenic milk effects disappeared when donor mice were injected with CD25 monoclonal antibodies during the lactation period, suggesting a CD4 +CD25 + regulatory T cell-dependent mechanism. Our results suggest a previously unknown impact of breastfeeding on the outcome of transplantation.

Original languageEnglish
Pages (from-to)1829-1833
Number of pages5
JournalBlood
Volume113
Issue number8
DOIs
Publication statusPublished - Feb 19 2009

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Homologous Transplantation
Breast Feeding
Bone Marrow Transplantation
Bone
Mothers
Antigens
Graft vs Host Disease
Grafts
Transplantation
T-cells
Human Milk
Regulatory T-Lymphocytes
Lactation
Milk
Monoclonal Antibodies
Parturition
Pregnancy

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Aoyama, K., Koyama, M., Matsuoka, K. I., Hashimoto, D., Ichinohe, T., Harada, M., ... Teshima, T. (2009). Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens. Blood, 113(8), 1829-1833. https://doi.org/10.1182/blood-2008-05-155283

Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens. / Aoyama, Kazutoshi; Koyama, Motoko; Matsuoka, Ken Ichi; Hashimoto, Daigo; Ichinohe, Tatsuo; Harada, Mine; Akashi, Koichi; Tanimoto, Mitsune; Teshima, Takanori.

In: Blood, Vol. 113, No. 8, 19.02.2009, p. 1829-1833.

Research output: Contribution to journalArticle

Aoyama, K, Koyama, M, Matsuoka, KI, Hashimoto, D, Ichinohe, T, Harada, M, Akashi, K, Tanimoto, M & Teshima, T 2009, 'Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens', Blood, vol. 113, no. 8, pp. 1829-1833. https://doi.org/10.1182/blood-2008-05-155283
Aoyama, Kazutoshi ; Koyama, Motoko ; Matsuoka, Ken Ichi ; Hashimoto, Daigo ; Ichinohe, Tatsuo ; Harada, Mine ; Akashi, Koichi ; Tanimoto, Mitsune ; Teshima, Takanori. / Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens. In: Blood. 2009 ; Vol. 113, No. 8. pp. 1829-1833.
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