Improvement of cognitive functions by oral intake of Hericium erinaceus

Yuusuke Saitsu, Akemi Nishide, Kenji Kikushima, Kuniyoshi Shimizu, Koichiro Ohnuki

Research output: Contribution to journalArticle

Abstract

Hericium erinaceus has been recognized as medical mushroom since ancient time, but its scientific evidence for human health has been still uncertain. In this study, we tested a randomized, double-blind, placebo-controlled parallel-group comparative study to evaluate the improvement of the cognitive functions by taking supplements containing fruiting body of H. erinaceus for 12 weeks. We performed three kinds of tests: Mini Mental State Examination (MMSE), Benton visual retention test, and Standard verbal paired-associate learning test (S-PA). MMSE alone showed that oral intake of H. erinaceus significantly improved cognitive functions and prevented from the deterioration. We speculate that various chemical compounds, including hericenones, in the mushroom have multiple effects to the brain neural networks and improve cognitive functions. Oral intake of H.erinaceus is safe and convenient method for dementia prevention so far.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalBiomedical research (Tokyo, Japan)
Volume40
Issue number4
DOIs
Publication statusPublished - Jan 1 2019

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Cognition
Agaricales
Paired-Associate Learning
Verbal Learning
Intelligence Tests
Chemical compounds
Deterioration
Dementia
Brain
Placebos
Health
Neural networks
Retention (Psychology)

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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Improvement of cognitive functions by oral intake of Hericium erinaceus. / Saitsu, Yuusuke; Nishide, Akemi; Kikushima, Kenji; Shimizu, Kuniyoshi; Ohnuki, Koichiro.

In: Biomedical research (Tokyo, Japan), Vol. 40, No. 4, 01.01.2019, p. 125-131.

Research output: Contribution to journalArticle

Saitsu, Yuusuke ; Nishide, Akemi ; Kikushima, Kenji ; Shimizu, Kuniyoshi ; Ohnuki, Koichiro. / Improvement of cognitive functions by oral intake of Hericium erinaceus. In: Biomedical research (Tokyo, Japan). 2019 ; Vol. 40, No. 4. pp. 125-131.
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