Improvement of compressive properties of porous HA scaffold by introducing PCL secondary phase

Phanny Yos, Mitsugu Todo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Continuous porous hydroxyapatite (HA) scaffold has been considered to be used in bone tissue engineering. However, the low fracture property of HA scaffold has been a problem to be solved. In the present study, polycaprolactone (PCL) was introduced as a secondary phase into the porous structure of HA scaffold to improve the low fracture property. HA scaffolds were firstly fabricated using the template method. The HA scaffolds were then coated with PCL by changing the solution concentration from 1 to 5 wt%. Compression tests and SEM were done to examine the mechanical properties and the morphology of the two-phase composite scaffolds. It was found that the compression strength and modulus increased with increasing PCL concentration. It is also noted that PCL coating can greatly improve the brittleness of pure HA scaffolds. XRD test was also done to study the phase stability of HA and the two-phase scaffolds. There was no chemical reaction between PCL and HA observed by the XRD results. On the overall, these results indicated that PCL coating can effectively improve the low fracture property of pure HA scaffold and the two-phase scaffold could be a potential candidate for bone regeneration.

Original languageEnglish
Title of host publicationFrontiers in Materials and Minerals Engineering
Pages96-102
Number of pages7
DOIs
Publication statusPublished - Jan 8 2014
Event5th Regional Conference on Materials Engineering and the 5th Regional Conference on Natural Resources and Materials 2013, RCM5 and RCNRM5 2013 - , Malaysia
Duration: Jan 22 2013Jan 23 2013

Publication series

NameAdvanced Materials Research
Volume858
ISSN (Print)1022-6680

Other

Other5th Regional Conference on Materials Engineering and the 5th Regional Conference on Natural Resources and Materials 2013, RCM5 and RCNRM5 2013
CountryMalaysia
Period1/22/131/23/13

Fingerprint

Polycaprolactone
Hydroxyapatite
Scaffolds
Bone
Compaction
Coatings
Phase stability
Brittleness
Tissue engineering
Chemical reactions
Mechanical properties

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Yos, P., & Todo, M. (2014). Improvement of compressive properties of porous HA scaffold by introducing PCL secondary phase. In Frontiers in Materials and Minerals Engineering (pp. 96-102). (Advanced Materials Research; Vol. 858). https://doi.org/10.4028/www.scientific.net/AMR.858.96

Improvement of compressive properties of porous HA scaffold by introducing PCL secondary phase. / Yos, Phanny; Todo, Mitsugu.

Frontiers in Materials and Minerals Engineering. 2014. p. 96-102 (Advanced Materials Research; Vol. 858).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yos, P & Todo, M 2014, Improvement of compressive properties of porous HA scaffold by introducing PCL secondary phase. in Frontiers in Materials and Minerals Engineering. Advanced Materials Research, vol. 858, pp. 96-102, 5th Regional Conference on Materials Engineering and the 5th Regional Conference on Natural Resources and Materials 2013, RCM5 and RCNRM5 2013, Malaysia, 1/22/13. https://doi.org/10.4028/www.scientific.net/AMR.858.96
Yos P, Todo M. Improvement of compressive properties of porous HA scaffold by introducing PCL secondary phase. In Frontiers in Materials and Minerals Engineering. 2014. p. 96-102. (Advanced Materials Research). https://doi.org/10.4028/www.scientific.net/AMR.858.96
Yos, Phanny ; Todo, Mitsugu. / Improvement of compressive properties of porous HA scaffold by introducing PCL secondary phase. Frontiers in Materials and Minerals Engineering. 2014. pp. 96-102 (Advanced Materials Research).
@inproceedings{e067d6af9bb24e969d25327d633ce043,
title = "Improvement of compressive properties of porous HA scaffold by introducing PCL secondary phase",
abstract = "Continuous porous hydroxyapatite (HA) scaffold has been considered to be used in bone tissue engineering. However, the low fracture property of HA scaffold has been a problem to be solved. In the present study, polycaprolactone (PCL) was introduced as a secondary phase into the porous structure of HA scaffold to improve the low fracture property. HA scaffolds were firstly fabricated using the template method. The HA scaffolds were then coated with PCL by changing the solution concentration from 1 to 5 wt{\%}. Compression tests and SEM were done to examine the mechanical properties and the morphology of the two-phase composite scaffolds. It was found that the compression strength and modulus increased with increasing PCL concentration. It is also noted that PCL coating can greatly improve the brittleness of pure HA scaffolds. XRD test was also done to study the phase stability of HA and the two-phase scaffolds. There was no chemical reaction between PCL and HA observed by the XRD results. On the overall, these results indicated that PCL coating can effectively improve the low fracture property of pure HA scaffold and the two-phase scaffold could be a potential candidate for bone regeneration.",
author = "Phanny Yos and Mitsugu Todo",
year = "2014",
month = "1",
day = "8",
doi = "10.4028/www.scientific.net/AMR.858.96",
language = "English",
isbn = "9783037859056",
series = "Advanced Materials Research",
pages = "96--102",
booktitle = "Frontiers in Materials and Minerals Engineering",

}

TY - GEN

T1 - Improvement of compressive properties of porous HA scaffold by introducing PCL secondary phase

AU - Yos, Phanny

AU - Todo, Mitsugu

PY - 2014/1/8

Y1 - 2014/1/8

N2 - Continuous porous hydroxyapatite (HA) scaffold has been considered to be used in bone tissue engineering. However, the low fracture property of HA scaffold has been a problem to be solved. In the present study, polycaprolactone (PCL) was introduced as a secondary phase into the porous structure of HA scaffold to improve the low fracture property. HA scaffolds were firstly fabricated using the template method. The HA scaffolds were then coated with PCL by changing the solution concentration from 1 to 5 wt%. Compression tests and SEM were done to examine the mechanical properties and the morphology of the two-phase composite scaffolds. It was found that the compression strength and modulus increased with increasing PCL concentration. It is also noted that PCL coating can greatly improve the brittleness of pure HA scaffolds. XRD test was also done to study the phase stability of HA and the two-phase scaffolds. There was no chemical reaction between PCL and HA observed by the XRD results. On the overall, these results indicated that PCL coating can effectively improve the low fracture property of pure HA scaffold and the two-phase scaffold could be a potential candidate for bone regeneration.

AB - Continuous porous hydroxyapatite (HA) scaffold has been considered to be used in bone tissue engineering. However, the low fracture property of HA scaffold has been a problem to be solved. In the present study, polycaprolactone (PCL) was introduced as a secondary phase into the porous structure of HA scaffold to improve the low fracture property. HA scaffolds were firstly fabricated using the template method. The HA scaffolds were then coated with PCL by changing the solution concentration from 1 to 5 wt%. Compression tests and SEM were done to examine the mechanical properties and the morphology of the two-phase composite scaffolds. It was found that the compression strength and modulus increased with increasing PCL concentration. It is also noted that PCL coating can greatly improve the brittleness of pure HA scaffolds. XRD test was also done to study the phase stability of HA and the two-phase scaffolds. There was no chemical reaction between PCL and HA observed by the XRD results. On the overall, these results indicated that PCL coating can effectively improve the low fracture property of pure HA scaffold and the two-phase scaffold could be a potential candidate for bone regeneration.

UR - http://www.scopus.com/inward/record.url?scp=84891619440&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891619440&partnerID=8YFLogxK

U2 - 10.4028/www.scientific.net/AMR.858.96

DO - 10.4028/www.scientific.net/AMR.858.96

M3 - Conference contribution

SN - 9783037859056

T3 - Advanced Materials Research

SP - 96

EP - 102

BT - Frontiers in Materials and Minerals Engineering

ER -