Improvement of diabetic or obese patients' erythrocyte deformability by the program of the brain-oriented obesity control system (BOOCS)

K. Saito, Keita Odashiro, Toru Maruyama, Koichi Akashi, S. Mawatari, T. Fujino

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Abstract

Diabetes is characterized by absolute or relative insulin deficiency complicated with microangiopathy, whereas obesity stems from insulin resistance. A psychosomatic approach to obesity and diabetes has been highlighted, including the brain-oriented obesity control system (BOOCS). Impaired deformability of erythrocytes in obese or diabetic patients is closely linked to disturbed microcirculation, and improvement of abnormal erythrocyte rheology is a prerequisite for the prevention and treatment of microangiopathy. Therefore, erythrocyte filterability, whole cell deformability defined as flow rate of erythrocyte suspension relative to that of saline, was assessed by the nickel-mesh-filtration technique. Subjects included healthy controls (group A, n = 14), diabetic, nonobese participants (group B, n = 29), and non-diabetic, obese participants (group C, n = 32) in the 6-month BOOCS program, and most patients in groups B and C (86.9 %) completed this program. Baseline mean erythrocyte filterabilities were 89.4 ± 1.7 % in group A, 82.8 ± 5.2 % in group B, and 84.1 ± 5.6 % in group C, showing significant intergroup differences (p<0.001). This program significantly improved (p<0.001) the impaired erythrocyte filterability in groups B (87.9 ± 4.4 %) and C (88.5 ± 3.7 %). Declines in HbA1c (p = 0.387) and body mass index (p = 0.479) were not correlated to this improvement. These findings indicate that the mechanisms of BOOCS-induced improvement of diabetic or obese patients' erythrocyte deformability are multifactorial, and that the BOOCS program for these patients is a holistic, cost-effective, and highly compliant approach possibly ameliorating microcirculation.

Original languageEnglish
Pages (from-to)445-451
Number of pages7
JournalJournal of Physiological Sciences
Volume62
Issue number6
DOIs
Publication statusPublished - Nov 1 2012

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Erythrocyte Deformability
Obesity
Brain
Microcirculation
Abnormal Erythrocytes
Rheology
Nickel
Insulin Resistance
Suspensions
Healthy Volunteers
Body Mass Index
Erythrocytes
Insulin
Costs and Cost Analysis
Control Groups

All Science Journal Classification (ASJC) codes

  • Physiology

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Improvement of diabetic or obese patients' erythrocyte deformability by the program of the brain-oriented obesity control system (BOOCS). / Saito, K.; Odashiro, Keita; Maruyama, Toru; Akashi, Koichi; Mawatari, S.; Fujino, T.

In: Journal of Physiological Sciences, Vol. 62, No. 6, 01.11.2012, p. 445-451.

Research output: Contribution to journalArticle

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