Improvement of glucose metabolism after a pancreatoduodenectomy

Ohtsuka Takao, Kenji Kitahara, Naohiko Kohya, Atsushi Miyoshi, Kohji Miyazaki

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVES: The aim of this study was to investigate the mechanisms of the change in glucose metabolism after a pancreatoduodenectomy (PD). METHODS: Oral glucose tolerance tests were performed in 17 patients before and 1 month after a PD. The changes in plasma glucose and insulin concentrations, homeostasis model of insulin resistance, and insulinogenic index (β-cell function) were analyzed. Two additional factors, gastric emptying function and plasma glucagon-like peptide-1 (GLP-1) concentration, that possibly affect perioperative glucose metabolism were also assessed. RESULTS: The plasma glucose and insulin concentrations were significantly lower after the operation, especially in preoperative diabetic patients. β-Cell function did not change after the operation. On the other hand, insulin resistance became normal 1 month after the operation. The value of gastric emptying function after the operation was not statistically different in comparison with that before the operation. Postoperative plasma GLP-1 concentration was significantly higher than the preoperative value. CONCLUSIONS: β-Cell function is maintained after a PD, whereas the improvement of insulin resistance may cause a short-term transient improvement of the glucose metabolism after the operation. The significance of increased postoperative GLP-1 concentration remains an unsolved issue.

Original languageEnglish
Pages (from-to)700-705
Number of pages6
JournalPancreas
Volume38
Issue number6
DOIs
Publication statusPublished - Aug 1 2009
Externally publishedYes

Fingerprint

Pancreaticoduodenectomy
Glucagon-Like Peptide 1
Glucose
Insulin Resistance
Gastric Emptying
Insulin
Glucose Tolerance Test
Homeostasis

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Takao, O., Kitahara, K., Kohya, N., Miyoshi, A., & Miyazaki, K. (2009). Improvement of glucose metabolism after a pancreatoduodenectomy. Pancreas, 38(6), 700-705. https://doi.org/10.1097/MPA.0b013e3181a7c916

Improvement of glucose metabolism after a pancreatoduodenectomy. / Takao, Ohtsuka; Kitahara, Kenji; Kohya, Naohiko; Miyoshi, Atsushi; Miyazaki, Kohji.

In: Pancreas, Vol. 38, No. 6, 01.08.2009, p. 700-705.

Research output: Contribution to journalArticle

Takao, O, Kitahara, K, Kohya, N, Miyoshi, A & Miyazaki, K 2009, 'Improvement of glucose metabolism after a pancreatoduodenectomy', Pancreas, vol. 38, no. 6, pp. 700-705. https://doi.org/10.1097/MPA.0b013e3181a7c916
Takao, Ohtsuka ; Kitahara, Kenji ; Kohya, Naohiko ; Miyoshi, Atsushi ; Miyazaki, Kohji. / Improvement of glucose metabolism after a pancreatoduodenectomy. In: Pancreas. 2009 ; Vol. 38, No. 6. pp. 700-705.
@article{e5aaa0abfb9944eab98813a329119e2d,
title = "Improvement of glucose metabolism after a pancreatoduodenectomy",
abstract = "OBJECTIVES: The aim of this study was to investigate the mechanisms of the change in glucose metabolism after a pancreatoduodenectomy (PD). METHODS: Oral glucose tolerance tests were performed in 17 patients before and 1 month after a PD. The changes in plasma glucose and insulin concentrations, homeostasis model of insulin resistance, and insulinogenic index (β-cell function) were analyzed. Two additional factors, gastric emptying function and plasma glucagon-like peptide-1 (GLP-1) concentration, that possibly affect perioperative glucose metabolism were also assessed. RESULTS: The plasma glucose and insulin concentrations were significantly lower after the operation, especially in preoperative diabetic patients. β-Cell function did not change after the operation. On the other hand, insulin resistance became normal 1 month after the operation. The value of gastric emptying function after the operation was not statistically different in comparison with that before the operation. Postoperative plasma GLP-1 concentration was significantly higher than the preoperative value. CONCLUSIONS: β-Cell function is maintained after a PD, whereas the improvement of insulin resistance may cause a short-term transient improvement of the glucose metabolism after the operation. The significance of increased postoperative GLP-1 concentration remains an unsolved issue.",
author = "Ohtsuka Takao and Kenji Kitahara and Naohiko Kohya and Atsushi Miyoshi and Kohji Miyazaki",
year = "2009",
month = "8",
day = "1",
doi = "10.1097/MPA.0b013e3181a7c916",
language = "English",
volume = "38",
pages = "700--705",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Improvement of glucose metabolism after a pancreatoduodenectomy

AU - Takao, Ohtsuka

AU - Kitahara, Kenji

AU - Kohya, Naohiko

AU - Miyoshi, Atsushi

AU - Miyazaki, Kohji

PY - 2009/8/1

Y1 - 2009/8/1

N2 - OBJECTIVES: The aim of this study was to investigate the mechanisms of the change in glucose metabolism after a pancreatoduodenectomy (PD). METHODS: Oral glucose tolerance tests were performed in 17 patients before and 1 month after a PD. The changes in plasma glucose and insulin concentrations, homeostasis model of insulin resistance, and insulinogenic index (β-cell function) were analyzed. Two additional factors, gastric emptying function and plasma glucagon-like peptide-1 (GLP-1) concentration, that possibly affect perioperative glucose metabolism were also assessed. RESULTS: The plasma glucose and insulin concentrations were significantly lower after the operation, especially in preoperative diabetic patients. β-Cell function did not change after the operation. On the other hand, insulin resistance became normal 1 month after the operation. The value of gastric emptying function after the operation was not statistically different in comparison with that before the operation. Postoperative plasma GLP-1 concentration was significantly higher than the preoperative value. CONCLUSIONS: β-Cell function is maintained after a PD, whereas the improvement of insulin resistance may cause a short-term transient improvement of the glucose metabolism after the operation. The significance of increased postoperative GLP-1 concentration remains an unsolved issue.

AB - OBJECTIVES: The aim of this study was to investigate the mechanisms of the change in glucose metabolism after a pancreatoduodenectomy (PD). METHODS: Oral glucose tolerance tests were performed in 17 patients before and 1 month after a PD. The changes in plasma glucose and insulin concentrations, homeostasis model of insulin resistance, and insulinogenic index (β-cell function) were analyzed. Two additional factors, gastric emptying function and plasma glucagon-like peptide-1 (GLP-1) concentration, that possibly affect perioperative glucose metabolism were also assessed. RESULTS: The plasma glucose and insulin concentrations were significantly lower after the operation, especially in preoperative diabetic patients. β-Cell function did not change after the operation. On the other hand, insulin resistance became normal 1 month after the operation. The value of gastric emptying function after the operation was not statistically different in comparison with that before the operation. Postoperative plasma GLP-1 concentration was significantly higher than the preoperative value. CONCLUSIONS: β-Cell function is maintained after a PD, whereas the improvement of insulin resistance may cause a short-term transient improvement of the glucose metabolism after the operation. The significance of increased postoperative GLP-1 concentration remains an unsolved issue.

UR - http://www.scopus.com/inward/record.url?scp=68949086417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68949086417&partnerID=8YFLogxK

U2 - 10.1097/MPA.0b013e3181a7c916

DO - 10.1097/MPA.0b013e3181a7c916

M3 - Article

VL - 38

SP - 700

EP - 705

JO - Pancreas

JF - Pancreas

SN - 0885-3177

IS - 6

ER -