Improvement of schizophrenic symptoms and changes in plasma HVA concentrations, plasma anti-D2 and anti-5-HT2 receptor activities with clozapine

Kazuo Yamada, Shigenobu Kanba, Zu Cheng Wang, Eiji Suzuki, Yi Yu Fang, He Gin Yan, Masashi Nibuya, Gohei Yagi, Masahiro Asai

Research output: Contribution to journalArticlepeer-review


In order to investigate the biological mechanisms underlying the clinical efficacy of clozapine, 200 mg/day of clozapine was added to the drug regimens of 19 patients with chronic, anti-psychotic-resistant schizophrenia, and the plasma homovanillic acid (HVA), clozapine concentrations, anti- dopamine D2 and anti-serotonin 5-HT2 receptor activities were measured. After 28 days, six patients showed an improvement of more than 20% over baseline Brief Psychiatric Rating Scale (BPRS) scores. Mean plasma HVA concentrations and anti-D2 receptor activities did not change significantly in the entire group or in the six patients showing improvement. However, anti-5-HT2 receptor activities increased significantly in all 19 patients. Changes in BPRS scores did not correlate significantly with changes in plasma HVA or with changes in clozapine concentrations, or with anti-D2 and anti- 5-HT2 receptor activities.

Original languageEnglish
Pages (from-to)291-294
Number of pages4
JournalPsychiatry and clinical neurosciences
Issue number5
Publication statusPublished - Oct 1996

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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