Improvement of sensitivity of multisample biological immunoassay system using HTS SQUID and magnetic nanoparticles

A. Tsukamoto, K. Saitoh, N. Sugita, H. Kuma, Y. Sugiura, S. Hamaoka, N. Hamasaki, K. Enpuku

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Recently, we have developed a prototype magnetic immunoassay system using a high temperature superconductor (HTS) superconducting quantum interference device (SQUID) to investigate the performance and usability of the magnetic immunoassay. In this study, we improved the immunoassay system to heighten the sensitivity of the immunoassay measurement. To reduce the SQUID-to-sample distance, we introduced a structure to compensate for thermal shrinkage in the cryostat and reduce the warpage of the window. The shape of pickup coil was also optimized to improve the field sensitivity. After these improvements, the magnetic signal intensity from Fe3O4 nanoparticles became about two times stronger than that achieved by our original system.

Original languageEnglish
Pages (from-to)975-978
Number of pages4
JournalPhysica C: Superconductivity and its applications
Volume445-448
Issue number1-2
DOIs
Publication statusPublished - Oct 1 2006

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immunoassay
High temperature superconductors
SQUIDs
Biological systems
high temperature superconductors
Nanoparticles
interference
nanoparticles
Cryostats
Pickups
sensitivity
warpage
magnetic signals
cryostats
shrinkage
coils
prototypes
sensors
Hot Temperature

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Energy Engineering and Power Technology
  • Electrical and Electronic Engineering

Cite this

Improvement of sensitivity of multisample biological immunoassay system using HTS SQUID and magnetic nanoparticles. / Tsukamoto, A.; Saitoh, K.; Sugita, N.; Kuma, H.; Sugiura, Y.; Hamaoka, S.; Hamasaki, N.; Enpuku, K.

In: Physica C: Superconductivity and its applications, Vol. 445-448, No. 1-2, 01.10.2006, p. 975-978.

Research output: Contribution to journalArticle

Tsukamoto, A, Saitoh, K, Sugita, N, Kuma, H, Sugiura, Y, Hamaoka, S, Hamasaki, N & Enpuku, K 2006, 'Improvement of sensitivity of multisample biological immunoassay system using HTS SQUID and magnetic nanoparticles', Physica C: Superconductivity and its applications, vol. 445-448, no. 1-2, pp. 975-978. https://doi.org/10.1016/j.physc.2006.06.019
Tsukamoto, A. ; Saitoh, K. ; Sugita, N. ; Kuma, H. ; Sugiura, Y. ; Hamaoka, S. ; Hamasaki, N. ; Enpuku, K. / Improvement of sensitivity of multisample biological immunoassay system using HTS SQUID and magnetic nanoparticles. In: Physica C: Superconductivity and its applications. 2006 ; Vol. 445-448, No. 1-2. pp. 975-978.
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