デンプン賦形調剤の改善

Translated title of the contribution: Improving Preparation of Powder Medicines with Starch Diluent

山内 結衣, 峯 昌敏, 中島 和博, 末安 正典, 江頭 伸昭, 大石 了三

Research output: Contribution to journalArticlepeer-review

Abstract

Starch is often used as a pharmaceutical diluent in dispensing.However,starch is susceptible to large errors in dividing weight because of its low fluidity.In the present study,we prepared granulated starch and a potato starch containing a stearic acid magnesium salt (St-starch) to improve the dispensing of powder medicines with starch diluent.These 2 starch diluents caused no problems in dispensing powder medicines in terms of pharmaceutical characteristics.In a dividing test,the coefficients of variation (C.V.) of the granulated starch and St-starch were much less than for potato starch,and met the dispensing criteria.In addition in the evaluation of ease of handling,St-starch was the best.Furthermore,the time for preparing the St-starch was much shorter (20 minutes for 2 persons) than that for granulated starch (3.5 hours).These results clearly show that St-starch is a useful starch diluent and enhances efficiency in the preparation of powder medicines with starch.
Translated title of the contributionImproving Preparation of Powder Medicines with Starch Diluent
Original languageJapanese
Pages (from-to)684-688
Number of pages5
Journal医療薬学
Volume36
Issue number9
DOIs
Publication statusPublished - 2010

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