In synergy with noggin and follistatin, Xenopus nodal-related gene induces sonic hedgehog on notochord and floor plate

Yuzuru Ito, Satoru Kuhara, Kosuke Tashiro

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In early development of vertebrates, sonic hedgehog functions in dorsal-ventral patterning of dorsal tissue (nervous system and somites). In Xenopus, sonic hedgehog (Xshh) is first expressed in the Spemann organizer/notochord and floor plate. We report here the mechanism governing Xshh mRNA induction in these regions. In animal cap assays, the antagonizing BMPs signal was not sufficient to induce Xshh mRNA expression; however, it could induce Xshh mRNA expression in the presence of Xnr-1. In whole embryos, when secondary axes were induced by coexpressing noggin and Xnr-1 or follistatin and Xnr-1, Xshh mRNA expression was observed in the notochord and floor plate within the induced axes. It seems apparent that spatially restricted Xshh mRNA expression is determined as intersection of the two signals.

Original languageEnglish
Pages (from-to)714-719
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume281
Issue number3
DOIs
Publication statusPublished - Jan 1 2001

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Follistatin
Notochord
Hedgehogs
Xenopus
Genes
Messenger RNA
Embryonic Organizers
Neurology
Somites
Assays
Animals
Tissue
Nervous System
Vertebrates
Embryonic Structures

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

In synergy with noggin and follistatin, Xenopus nodal-related gene induces sonic hedgehog on notochord and floor plate. / Ito, Yuzuru; Kuhara, Satoru; Tashiro, Kosuke.

In: Biochemical and Biophysical Research Communications, Vol. 281, No. 3, 01.01.2001, p. 714-719.

Research output: Contribution to journalArticle

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