In Vitro Cytocompatibility of Osteoblastic Cells Cultured on Chitosan-Organosiloxane Hybrid Membrane

Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, M. A. Lopes, J. D. Santos, M. H. Fernandes

Research output: Contribution to journalConference articlepeer-review

3 Citations (Scopus)

Abstract

Chitosan-silicate hybrids were synthesized using γ-glycidoxypropyltrimethoxysilane (GPSM) as the agent to cross-link the chitosan chains. Fourier-transform infrared (PT-IR) spectroscopy was used to analyze the structures of the hybrids. The swelling ability and the cytocompatibility of the hybrids were investigated as a function of the GPSM concentration. The swelling of the hybrids was suppressed by addition of GPSM. MG63 human osteoblastic cells were cultured on the hybrids. The adhesion and proliferation of the MG63 cells cultured on the chitosan-GPSM hybrid surface were improved comparing to that on chitosan membrane, regardless the GPSM concentration.

Original languageEnglish
Pages (from-to)857-860
Number of pages4
JournalKey Engineering Materials
Volume254-256
Publication statusPublished - Jan 1 2004
Externally publishedYes
EventThe Annual Meeting of the International Society for Ceramics in Medicine - Porto, Portugal
Duration: Nov 6 2003Nov 9 2003

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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