In vitro susceptibilities to levofloxacin and various antibacterial agents of 12,919 clinical isolates obtained from 72 centers in 2007

Yamaguchi Keizo Yamaguchi, Akira Ohno, Yoshikazu Ishii, Kazuhiro Tateda, Morihiro Iwata, Makotokanda, Koun Akizawa, Chikara Shimizu, Shinichirou Kon, Kastushi Nakamura, Keiko Matsuda, Makoto Tomtnaga, Takuo Nakagawa, Akthiro Sugita, Tatsumi Ito, Junkato, Akira Suwabe, Kumiko Yamahata, Chizuko Kawamura, Hiromi TashiroHiroko Horiuchi, Yosei Katayama, Minoru Yasujima, Makoto Miki, Masato Hayashi, Syunji Okubo, Syunkou Toyoshima, Mitsuo Kaku, Imao Serine, Joji Shiotani, Hajime Horiuchi, Yoko Tazawa, Akiko Yoneyama, Kazunari Kumasaka, Kazuhiko Koike, Dongchon Kang, Junko Ono, Koichi Mashiba

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Abstract

We have reported in this journal in vitro susceptibilities of clinical isolates to antibiotics every year since 1992. In this paper, we report the results of an analysis of in vitro susceptibilities of 12,919 clinical isolates from 72 centers in Japan to selected antibiotics in 2007 compared with the results from previous years. The common respiratory pathogens, Streptococcus pyogenes, Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae maintained a high susceptibility to fluoroquinolones (FQs). The resistance of 5. pyogenes to macrolides has been increasing every year and this was especially clear this year. Most strains of Enterobacteriaceae except for Escherichia coli showed a high susceptibility to FQs. Almost 30% of E. coli strains were resistant to FQs and the resistance increased further this year. FQs resistance of methicillin-resistant Staphylococcus aureus (MRSA) was approximately 95% with the exception of 45% for sitafloxacin (STFX). FQs resistance of methicillin-susceptible S. aureus (MSSA) was low at about 10%. FQs resistance of methicillin-resistant coagulase negative Staphylococci (MRCNS) was higher than that of methicillin-susceptible coagulase negative Staphylococci (MSCNS), but it was lower than that of MRSA. However, FQs resistance of MSCNS was higher than that of MSSA. FQs resistance of Enterococcus faecalis was 22.5% to 29.6%, while that of Enterococcus faecium was more than 85% except for STFX (58.3%). In clinical isolates of Pseudomonas aeruginosa derived from urinary tract infections, FQs resistance was 21-27%, which was higher than that of/? aeruginosa from respiratory tract infections at 13-21%, which was the same trend as in past years. Multidrug resistant strains accounted for 5.6% in the urinary tract and 1.8% in the respiratory tract. Acinetobacter spp. showed high susceptibility to FQs. The carbapenem resistant strains, which present a problem at present, accounted for 2.7%. Neisseria gonorrhoeae showed high resistance of 86-88% to FQs. The results of the present survey indicated that although methicillin-resistant Staphylococci, Enterococci, E. coli, P. aeruginosa, and N. gonorrhoeae showed resistance tendencies, and other species maintained high susceptibility rates more than 90% against FQs, which have been used clinically for over 15 years.

Original languageEnglish
Pages (from-to)346-370
Number of pages25
JournalJapanese Journal of Antibiotics
Volume62
Issue number4
Publication statusPublished - Dec 1 2009

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Levofloxacin
Fluoroquinolones
Anti-Bacterial Agents
Methicillin Resistance
Staphylococcus
Coagulase
Methicillin
Neisseria gonorrhoeae
Methicillin-Resistant Staphylococcus aureus
Escherichia coli
Pseudomonas aeruginosa
Staphylococcus aureus
In Vitro Techniques
Moraxella (Branhamella) catarrhalis
Enterococcus faecium
Acinetobacter
Carbapenems
Enterococcus faecalis
Streptococcus pyogenes
Macrolides

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Keizo Yamaguchi, Y., Ohno, A., Ishii, Y., Tateda, K., Iwata, M., Makotokanda, ... Mashiba, K. (2009). In vitro susceptibilities to levofloxacin and various antibacterial agents of 12,919 clinical isolates obtained from 72 centers in 2007. Japanese Journal of Antibiotics, 62(4), 346-370.

In vitro susceptibilities to levofloxacin and various antibacterial agents of 12,919 clinical isolates obtained from 72 centers in 2007. / Keizo Yamaguchi, Yamaguchi; Ohno, Akira; Ishii, Yoshikazu; Tateda, Kazuhiro; Iwata, Morihiro; Makotokanda; Akizawa, Koun; Shimizu, Chikara; Kon, Shinichirou; Nakamura, Kastushi; Matsuda, Keiko; Tomtnaga, Makoto; Nakagawa, Takuo; Sugita, Akthiro; Ito, Tatsumi; Junkato; Suwabe, Akira; Yamahata, Kumiko; Kawamura, Chizuko; Tashiro, Hiromi; Horiuchi, Hiroko; Katayama, Yosei; Yasujima, Minoru; Miki, Makoto; Hayashi, Masato; Okubo, Syunji; Toyoshima, Syunkou; Kaku, Mitsuo; Serine, Imao; Shiotani, Joji; Horiuchi, Hajime; Tazawa, Yoko; Yoneyama, Akiko; Kumasaka, Kazunari; Koike, Kazuhiko; Kang, Dongchon; Ono, Junko; Mashiba, Koichi.

In: Japanese Journal of Antibiotics, Vol. 62, No. 4, 01.12.2009, p. 346-370.

Research output: Contribution to journalArticle

Keizo Yamaguchi, Y, Ohno, A, Ishii, Y, Tateda, K, Iwata, M, Makotokanda, Akizawa, K, Shimizu, C, Kon, S, Nakamura, K, Matsuda, K, Tomtnaga, M, Nakagawa, T, Sugita, A, Ito, T, Junkato, Suwabe, A, Yamahata, K, Kawamura, C, Tashiro, H, Horiuchi, H, Katayama, Y, Yasujima, M, Miki, M, Hayashi, M, Okubo, S, Toyoshima, S, Kaku, M, Serine, I, Shiotani, J, Horiuchi, H, Tazawa, Y, Yoneyama, A, Kumasaka, K, Koike, K, Kang, D, Ono, J & Mashiba, K 2009, 'In vitro susceptibilities to levofloxacin and various antibacterial agents of 12,919 clinical isolates obtained from 72 centers in 2007', Japanese Journal of Antibiotics, vol. 62, no. 4, pp. 346-370.
Keizo Yamaguchi, Yamaguchi ; Ohno, Akira ; Ishii, Yoshikazu ; Tateda, Kazuhiro ; Iwata, Morihiro ; Makotokanda ; Akizawa, Koun ; Shimizu, Chikara ; Kon, Shinichirou ; Nakamura, Kastushi ; Matsuda, Keiko ; Tomtnaga, Makoto ; Nakagawa, Takuo ; Sugita, Akthiro ; Ito, Tatsumi ; Junkato ; Suwabe, Akira ; Yamahata, Kumiko ; Kawamura, Chizuko ; Tashiro, Hiromi ; Horiuchi, Hiroko ; Katayama, Yosei ; Yasujima, Minoru ; Miki, Makoto ; Hayashi, Masato ; Okubo, Syunji ; Toyoshima, Syunkou ; Kaku, Mitsuo ; Serine, Imao ; Shiotani, Joji ; Horiuchi, Hajime ; Tazawa, Yoko ; Yoneyama, Akiko ; Kumasaka, Kazunari ; Koike, Kazuhiko ; Kang, Dongchon ; Ono, Junko ; Mashiba, Koichi. / In vitro susceptibilities to levofloxacin and various antibacterial agents of 12,919 clinical isolates obtained from 72 centers in 2007. In: Japanese Journal of Antibiotics. 2009 ; Vol. 62, No. 4. pp. 346-370.
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abstract = "We have reported in this journal in vitro susceptibilities of clinical isolates to antibiotics every year since 1992. In this paper, we report the results of an analysis of in vitro susceptibilities of 12,919 clinical isolates from 72 centers in Japan to selected antibiotics in 2007 compared with the results from previous years. The common respiratory pathogens, Streptococcus pyogenes, Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae maintained a high susceptibility to fluoroquinolones (FQs). The resistance of 5. pyogenes to macrolides has been increasing every year and this was especially clear this year. Most strains of Enterobacteriaceae except for Escherichia coli showed a high susceptibility to FQs. Almost 30{\%} of E. coli strains were resistant to FQs and the resistance increased further this year. FQs resistance of methicillin-resistant Staphylococcus aureus (MRSA) was approximately 95{\%} with the exception of 45{\%} for sitafloxacin (STFX). FQs resistance of methicillin-susceptible S. aureus (MSSA) was low at about 10{\%}. FQs resistance of methicillin-resistant coagulase negative Staphylococci (MRCNS) was higher than that of methicillin-susceptible coagulase negative Staphylococci (MSCNS), but it was lower than that of MRSA. However, FQs resistance of MSCNS was higher than that of MSSA. FQs resistance of Enterococcus faecalis was 22.5{\%} to 29.6{\%}, while that of Enterococcus faecium was more than 85{\%} except for STFX (58.3{\%}). In clinical isolates of Pseudomonas aeruginosa derived from urinary tract infections, FQs resistance was 21-27{\%}, which was higher than that of/? aeruginosa from respiratory tract infections at 13-21{\%}, which was the same trend as in past years. Multidrug resistant strains accounted for 5.6{\%} in the urinary tract and 1.8{\%} in the respiratory tract. Acinetobacter spp. showed high susceptibility to FQs. The carbapenem resistant strains, which present a problem at present, accounted for 2.7{\%}. Neisseria gonorrhoeae showed high resistance of 86-88{\%} to FQs. The results of the present survey indicated that although methicillin-resistant Staphylococci, Enterococci, E. coli, P. aeruginosa, and N. gonorrhoeae showed resistance tendencies, and other species maintained high susceptibility rates more than 90{\%} against FQs, which have been used clinically for over 15 years.",
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TY - JOUR

T1 - In vitro susceptibilities to levofloxacin and various antibacterial agents of 12,919 clinical isolates obtained from 72 centers in 2007

AU - Keizo Yamaguchi, Yamaguchi

AU - Ohno, Akira

AU - Ishii, Yoshikazu

AU - Tateda, Kazuhiro

AU - Iwata, Morihiro

AU - Makotokanda,

AU - Akizawa, Koun

AU - Shimizu, Chikara

AU - Kon, Shinichirou

AU - Nakamura, Kastushi

AU - Matsuda, Keiko

AU - Tomtnaga, Makoto

AU - Nakagawa, Takuo

AU - Sugita, Akthiro

AU - Ito, Tatsumi

AU - Junkato,

AU - Suwabe, Akira

AU - Yamahata, Kumiko

AU - Kawamura, Chizuko

AU - Tashiro, Hiromi

AU - Horiuchi, Hiroko

AU - Katayama, Yosei

AU - Yasujima, Minoru

AU - Miki, Makoto

AU - Hayashi, Masato

AU - Okubo, Syunji

AU - Toyoshima, Syunkou

AU - Kaku, Mitsuo

AU - Serine, Imao

AU - Shiotani, Joji

AU - Horiuchi, Hajime

AU - Tazawa, Yoko

AU - Yoneyama, Akiko

AU - Kumasaka, Kazunari

AU - Koike, Kazuhiko

AU - Kang, Dongchon

AU - Ono, Junko

AU - Mashiba, Koichi

PY - 2009/12/1

Y1 - 2009/12/1

N2 - We have reported in this journal in vitro susceptibilities of clinical isolates to antibiotics every year since 1992. In this paper, we report the results of an analysis of in vitro susceptibilities of 12,919 clinical isolates from 72 centers in Japan to selected antibiotics in 2007 compared with the results from previous years. The common respiratory pathogens, Streptococcus pyogenes, Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae maintained a high susceptibility to fluoroquinolones (FQs). The resistance of 5. pyogenes to macrolides has been increasing every year and this was especially clear this year. Most strains of Enterobacteriaceae except for Escherichia coli showed a high susceptibility to FQs. Almost 30% of E. coli strains were resistant to FQs and the resistance increased further this year. FQs resistance of methicillin-resistant Staphylococcus aureus (MRSA) was approximately 95% with the exception of 45% for sitafloxacin (STFX). FQs resistance of methicillin-susceptible S. aureus (MSSA) was low at about 10%. FQs resistance of methicillin-resistant coagulase negative Staphylococci (MRCNS) was higher than that of methicillin-susceptible coagulase negative Staphylococci (MSCNS), but it was lower than that of MRSA. However, FQs resistance of MSCNS was higher than that of MSSA. FQs resistance of Enterococcus faecalis was 22.5% to 29.6%, while that of Enterococcus faecium was more than 85% except for STFX (58.3%). In clinical isolates of Pseudomonas aeruginosa derived from urinary tract infections, FQs resistance was 21-27%, which was higher than that of/? aeruginosa from respiratory tract infections at 13-21%, which was the same trend as in past years. Multidrug resistant strains accounted for 5.6% in the urinary tract and 1.8% in the respiratory tract. Acinetobacter spp. showed high susceptibility to FQs. The carbapenem resistant strains, which present a problem at present, accounted for 2.7%. Neisseria gonorrhoeae showed high resistance of 86-88% to FQs. The results of the present survey indicated that although methicillin-resistant Staphylococci, Enterococci, E. coli, P. aeruginosa, and N. gonorrhoeae showed resistance tendencies, and other species maintained high susceptibility rates more than 90% against FQs, which have been used clinically for over 15 years.

AB - We have reported in this journal in vitro susceptibilities of clinical isolates to antibiotics every year since 1992. In this paper, we report the results of an analysis of in vitro susceptibilities of 12,919 clinical isolates from 72 centers in Japan to selected antibiotics in 2007 compared with the results from previous years. The common respiratory pathogens, Streptococcus pyogenes, Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae maintained a high susceptibility to fluoroquinolones (FQs). The resistance of 5. pyogenes to macrolides has been increasing every year and this was especially clear this year. Most strains of Enterobacteriaceae except for Escherichia coli showed a high susceptibility to FQs. Almost 30% of E. coli strains were resistant to FQs and the resistance increased further this year. FQs resistance of methicillin-resistant Staphylococcus aureus (MRSA) was approximately 95% with the exception of 45% for sitafloxacin (STFX). FQs resistance of methicillin-susceptible S. aureus (MSSA) was low at about 10%. FQs resistance of methicillin-resistant coagulase negative Staphylococci (MRCNS) was higher than that of methicillin-susceptible coagulase negative Staphylococci (MSCNS), but it was lower than that of MRSA. However, FQs resistance of MSCNS was higher than that of MSSA. FQs resistance of Enterococcus faecalis was 22.5% to 29.6%, while that of Enterococcus faecium was more than 85% except for STFX (58.3%). In clinical isolates of Pseudomonas aeruginosa derived from urinary tract infections, FQs resistance was 21-27%, which was higher than that of/? aeruginosa from respiratory tract infections at 13-21%, which was the same trend as in past years. Multidrug resistant strains accounted for 5.6% in the urinary tract and 1.8% in the respiratory tract. Acinetobacter spp. showed high susceptibility to FQs. The carbapenem resistant strains, which present a problem at present, accounted for 2.7%. Neisseria gonorrhoeae showed high resistance of 86-88% to FQs. The results of the present survey indicated that although methicillin-resistant Staphylococci, Enterococci, E. coli, P. aeruginosa, and N. gonorrhoeae showed resistance tendencies, and other species maintained high susceptibility rates more than 90% against FQs, which have been used clinically for over 15 years.

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