In vivo Antioxidant activity and hepatoprotective effects of methanolic extract of Mesua ferrea linn

Sandeep Garg, Kameshwar Sharma, Rajeev Ranjan, Pankaj Attri, Parshuram Mishra

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Study was carried out to evaluate the antioxidant activity of dried flower methanolic extract of Mesua ferrea in male Wister rat. Methanolic extract of Mesua ferrea linn was taken in 3 graded doses (50, 100, and 200 mg/kg of BW) and were evaluated for their antioxidant activity and hepatoprotective effects. Rats were artificially inoculated with Staphylococcus aureus (ATCC 43300) in drinking water on the onset of experiment. After 24 h of bacteria inoculation, the methanolic extract was administered daily for 1 week. After 1 week, rats were sacrificed for their liver. The effect of Mesua extract was studied on antioxidant profile of liver. ALT, AST, CPK, Creatinine and urea profile were analyzed with standard procedures. Administration of Mesua ferrea flower extract in all the doses caused a significant increase in biochemical parameters and posed a hepatoprotective effect however in 100 mg/kg of BW, the effect was significant. CAT, SOD, GPx, and GR were measured for evaluation of antioxidant activity and found significantly higher activity in Mesua fed rats than control. AAT and AST showed a significant decrease in Mesua fed groups of Wister Rats. This investigation demonstrated the potent antioxidant activity of Mesua ferrea flower extract.

Original languageEnglish
Pages (from-to)1692-1696
Number of pages5
JournalInternational Journal of PharmTech Research
Volume1
Issue number4
Publication statusPublished - Oct 1 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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