In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by N-methyl-d-aspartate receptor blockers

Motoomi Nakamura, Shimako Abe, Yoshinobu Goto, Akiko Chishaki, Kouhei Akazawa, Motohiro Kato

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The behavioral changes associated with seizures induced by auditory stimulation in magnesium (Mg)-deficient rats originate in deep brain structures and secondarily project to neocortex. In the present study, we examined the roles of N-methyl-d-aspartate (NMDA) receptors in this seizure model. The intraperitoneal administration of the competitive NMDA receptor blocker dl-2-amino-7-phosphonoheptanoic acid (36 and 72 mg/kg) and the non-competitive NMDA receptor blocker MK-801 (1.35 and 2.7 mg/kg), completely prevented the induction of seizure and bradyarrhythmia or sudden death resulting from seizure. Therefore, the white-noise-induced seizures in Mg-deficient rats are linked to increased neuronal excitability via the NMDA receptor.

Original languageEnglish
Pages (from-to)249-256
Number of pages8
JournalEpilepsy Research
Volume17
Issue number3
DOIs
Publication statusPublished - Mar 1994

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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