In vivo-CT system with respiratory and cardiac gating using synchrotron radiation

Toshihiro Sera, Hideo Yokota, Kazuhiro Fujisaki, Kazuaki Fukasaku, Kentaro Uesugi, Naoto Yagi, Ryutaro Himeno

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The interest in using small animal models of human disease has produced a need to design a CT system at a microscopic level comparable to that achievable in a clinical CT in human. In this study, we developed a high-resolution in vivo-CT system with respiratory and cardiac gating using synchrotron radiation. The system was constructed in BL20B2 at SPring-8. SPring-8 is the third generation synchrotron radiation source in Hyogo, Japan, and prefers much higher flux X-ray than a laboratory X-ray source. Another advantage of synchrotron monochromatic CT is the minimalization of beam hardening effects, which pose serious problems when using white X-rays. Since the X-ray beam from the synchrotron source is parallel, each horizontal line corresponds to a slice position along the rotation axis. Multiple slices are easily obtained in one rotation (3D-CT). For in vivo scanning, the X-ray mechanical shutter and CCD electrical shutter were synchronized with an airway pressure (respiratory) and electrocardiographic (ECG) signal. Synchronization reduced the motion artifacts caused by respiration and heart beats, markedly improving visualization of the edges of the heart, ribs and diaphragm. In particular, small airways (diameter > 300 μm) and cerebral blood vessels were visualized clearly. This system is very useful for evaluating lung physiology and cardiovascular mechanics in vivo.

Original languageEnglish
Title of host publicationMedical Imaging 2007
Subtitle of host publicationPhysiology, Function, and Structure from Medical Images
EditionPART 1
DOIs
Publication statusPublished - Oct 15 2007
Externally publishedYes
EventMedical Imaging 2007: Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
Duration: Feb 18 2007Feb 20 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
NumberPART 1
Volume6511
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2007: Physiology, Function, and Structure from Medical Images
CountryUnited States
CitySan Diego, CA
Period2/18/072/20/07

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Sera, T., Yokota, H., Fujisaki, K., Fukasaku, K., Uesugi, K., Yagi, N., & Himeno, R. (2007). In vivo-CT system with respiratory and cardiac gating using synchrotron radiation. In Medical Imaging 2007: Physiology, Function, and Structure from Medical Images (PART 1 ed.). [651103] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6511, No. PART 1). https://doi.org/10.1117/12.709619