In vivo diagnosis and therapy of human tumors with monoclonal antibodies

Selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung

James L. Mulshine, Ingalil Avis, Anthony M. Treston, Philip G. Kasprzyk, Yoichi Nakanishi, Cindy Mobley, Jorge A. Carrasquillo, Steven M. Larson, Bruce Merchant, Frank Cuttitta

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Initial monoclonal antibody therapy trials include an attempt to control malignant proliferation of small cell lung cancer by blocking the autocrine stimulation of gastrin releasing peptide. A critical issue is the adequacy of antibody penetration into the tumor bed to effect immunologic blockade of the mitogenic peptide. The use of an indium-111 antibody chelate which is coadministered with the first therapeutic antibody administration facilitates analysis of the pharmacokinetic dynamics for this trial. If this approach is successful with gastrin releasing peptide, other peptide hormones with autocrine effects could also be targeted. A combination of anti growth factor therapies could lead to successful therapeutic control of this lethal disease.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalInternational Journal of Radiation Applications and Instrumentation.
Volume16
Issue number2
DOIs
Publication statusPublished - Jan 1 1989
Externally publishedYes

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Small Cell Lung Carcinoma
Monoclonal Antibodies
Gastrin-Releasing Peptide
Antibodies
Neoplasms
Indium
Peptide Hormones
Therapeutics
Intercellular Signaling Peptides and Proteins
Pharmacokinetics
Peptides
Clinical Studies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

In vivo diagnosis and therapy of human tumors with monoclonal antibodies : Selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung. / Mulshine, James L.; Avis, Ingalil; Treston, Anthony M.; Kasprzyk, Philip G.; Nakanishi, Yoichi; Mobley, Cindy; Carrasquillo, Jorge A.; Larson, Steven M.; Merchant, Bruce; Cuttitta, Frank.

In: International Journal of Radiation Applications and Instrumentation., Vol. 16, No. 2, 01.01.1989, p. 159-162.

Research output: Contribution to journalArticle

Mulshine, James L. ; Avis, Ingalil ; Treston, Anthony M. ; Kasprzyk, Philip G. ; Nakanishi, Yoichi ; Mobley, Cindy ; Carrasquillo, Jorge A. ; Larson, Steven M. ; Merchant, Bruce ; Cuttitta, Frank. / In vivo diagnosis and therapy of human tumors with monoclonal antibodies : Selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung. In: International Journal of Radiation Applications and Instrumentation. 1989 ; Vol. 16, No. 2. pp. 159-162.
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