In vivo ESR measurements of free radical reactions in living mice

Hideo Utsumi, Kazuhiro Ichikawa, Keizo Takeshita

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Abstract

In vivo ESR measurements were carried out to estimate free radical reactions in living mice using nitroxyl radicals as probes. The ESR signal of nitroxyl radical which was intravenously or intramuscularly injected to living female ddY mice decreased gradually by reducing to the corresponding hydroxylamine. The reduction rate was enhanced by oxidative stress, and pre-treatment of antioxidants suppressed the enhancement of signal decay. Oral administration of carbon tetrachloride enhanced signal decay in upper abdomen but not m thorax. These results indicated that free radicals, which can reduce nitroxyl radical, were produced in the upper abdomen by oral administration of carbon tetrachloride.

Original languageEnglish
Pages (from-to)561-565
Number of pages5
JournalToxicology Letters
Volume82-83
Issue numberC
DOIs
Publication statusPublished - Dec 1995

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All Science Journal Classification (ASJC) codes

  • Toxicology

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