TY - JOUR
T1 - In vivo evaluation of bone-bonding of titanium metal chemically treated with a hydrogen peroxide solution containing tantalum chloride
AU - Kaneko, S.
AU - Tsuru, K.
AU - Hayakawa, S.
AU - Takemoto, S.
AU - Ohtsuki, C.
AU - Ozaki, T.
AU - Inoue, H.
AU - Osaka, A.
N1 - Funding Information:
A part of this research is funded by Okayama Foundation for Science and Technology. One of the authors (C.O.) gratefully acknowledges financial support of the Grant-in-Aid for Science Research, the Ministry of education, Science, Sports, and Culture, Japan.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001/5/1
Y1 - 2001/5/1
N2 - Apatite formation on implants is important in achieving a direct bonding to bone tissue. We recently showed that titanium metal chemically treated with a hydrogen peroxide solution containing tantalum chloride has the ability to form a hydroxyapatite layer in simulated body fluid which had inorganic ion composition similar to human blood plasma. In this study, a pure titanium cylinder (4.0mm in diameter, 20.0mm in length) treated with this method was implanted into a hole (4.2mm in diameter) in a rabbit's tibia. After implantation for predetermined periods up to 16 weeks, the specimens were extracted with bone tissue, and were examined by push-out test to evaluate the shearing force between the implant and bone tissue. The results were compared with those of non-treated pure titanium. Eight weeks after surgery, the shearing force of the treated titanium implanted in the 4.2mm-hole was significantly higher than that of non-treated titanium, although the surface roughness was not changed after the treatment. Scanning electron microscopic (SEM) observation and energy-dispersive X-ray (EDX) microanalysis showed that the bone comes very close to the surface of the treated titanium. Moreover, the shearing force was higher for the implanted sample in the 4.0mm-hole than that in the 4.2mm-hole. Thus, it is confirmed that the treatment with hydrogen peroxide solution containing tantalum chloride provides higher bonding ability on titanium implants in vivo.
AB - Apatite formation on implants is important in achieving a direct bonding to bone tissue. We recently showed that titanium metal chemically treated with a hydrogen peroxide solution containing tantalum chloride has the ability to form a hydroxyapatite layer in simulated body fluid which had inorganic ion composition similar to human blood plasma. In this study, a pure titanium cylinder (4.0mm in diameter, 20.0mm in length) treated with this method was implanted into a hole (4.2mm in diameter) in a rabbit's tibia. After implantation for predetermined periods up to 16 weeks, the specimens were extracted with bone tissue, and were examined by push-out test to evaluate the shearing force between the implant and bone tissue. The results were compared with those of non-treated pure titanium. Eight weeks after surgery, the shearing force of the treated titanium implanted in the 4.2mm-hole was significantly higher than that of non-treated titanium, although the surface roughness was not changed after the treatment. Scanning electron microscopic (SEM) observation and energy-dispersive X-ray (EDX) microanalysis showed that the bone comes very close to the surface of the treated titanium. Moreover, the shearing force was higher for the implanted sample in the 4.0mm-hole than that in the 4.2mm-hole. Thus, it is confirmed that the treatment with hydrogen peroxide solution containing tantalum chloride provides higher bonding ability on titanium implants in vivo.
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U2 - 10.1016/S0142-9612(01)00036-9
DO - 10.1016/S0142-9612(01)00036-9
M3 - Article
C2 - 11311005
AN - SCOPUS:0035342607
VL - 22
SP - 875
EP - 881
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 9
ER -