Abstract
Apatite formation on implants is important in achieving a direct bonding to bone tissue. We recently showed that titanium metal chemically treated with a hydrogen peroxide solution containing tantalum chloride has the ability to form a hydroxyapatite layer in simulated body fluid which had inorganic ion composition similar to human blood plasma. In this study, a pure titanium cylinder (4.0mm in diameter, 20.0mm in length) treated with this method was implanted into a hole (4.2mm in diameter) in a rabbit's tibia. After implantation for predetermined periods up to 16 weeks, the specimens were extracted with bone tissue, and were examined by push-out test to evaluate the shearing force between the implant and bone tissue. The results were compared with those of non-treated pure titanium. Eight weeks after surgery, the shearing force of the treated titanium implanted in the 4.2mm-hole was significantly higher than that of non-treated titanium, although the surface roughness was not changed after the treatment. Scanning electron microscopic (SEM) observation and energy-dispersive X-ray (EDX) microanalysis showed that the bone comes very close to the surface of the treated titanium. Moreover, the shearing force was higher for the implanted sample in the 4.0mm-hole than that in the 4.2mm-hole. Thus, it is confirmed that the treatment with hydrogen peroxide solution containing tantalum chloride provides higher bonding ability on titanium implants in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 875-881 |
| Number of pages | 7 |
| Journal | Biomaterials |
| Volume | 22 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - May 1 2001 |
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All Science Journal Classification (ASJC) codes
- Bioengineering
- Ceramics and Composites
- Biophysics
- Biomaterials
- Mechanics of Materials
Cite this
In vivo evaluation of bone-bonding of titanium metal chemically treated with a hydrogen peroxide solution containing tantalum chloride. / Kaneko, S.; Tsuru, Kanji; Hayakawa, S.; Takemoto, S.; Ohtsuki, C.; Ozaki, T.; Inoue, H.; Osaka, A.
In: Biomaterials, Vol. 22, No. 9, 01.05.2001, p. 875-881.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo evaluation of bone-bonding of titanium metal chemically treated with a hydrogen peroxide solution containing tantalum chloride
AU - Kaneko, S.
AU - Tsuru, Kanji
AU - Hayakawa, S.
AU - Takemoto, S.
AU - Ohtsuki, C.
AU - Ozaki, T.
AU - Inoue, H.
AU - Osaka, A.
PY - 2001/5/1
Y1 - 2001/5/1
N2 - Apatite formation on implants is important in achieving a direct bonding to bone tissue. We recently showed that titanium metal chemically treated with a hydrogen peroxide solution containing tantalum chloride has the ability to form a hydroxyapatite layer in simulated body fluid which had inorganic ion composition similar to human blood plasma. In this study, a pure titanium cylinder (4.0mm in diameter, 20.0mm in length) treated with this method was implanted into a hole (4.2mm in diameter) in a rabbit's tibia. After implantation for predetermined periods up to 16 weeks, the specimens were extracted with bone tissue, and were examined by push-out test to evaluate the shearing force between the implant and bone tissue. The results were compared with those of non-treated pure titanium. Eight weeks after surgery, the shearing force of the treated titanium implanted in the 4.2mm-hole was significantly higher than that of non-treated titanium, although the surface roughness was not changed after the treatment. Scanning electron microscopic (SEM) observation and energy-dispersive X-ray (EDX) microanalysis showed that the bone comes very close to the surface of the treated titanium. Moreover, the shearing force was higher for the implanted sample in the 4.0mm-hole than that in the 4.2mm-hole. Thus, it is confirmed that the treatment with hydrogen peroxide solution containing tantalum chloride provides higher bonding ability on titanium implants in vivo.
AB - Apatite formation on implants is important in achieving a direct bonding to bone tissue. We recently showed that titanium metal chemically treated with a hydrogen peroxide solution containing tantalum chloride has the ability to form a hydroxyapatite layer in simulated body fluid which had inorganic ion composition similar to human blood plasma. In this study, a pure titanium cylinder (4.0mm in diameter, 20.0mm in length) treated with this method was implanted into a hole (4.2mm in diameter) in a rabbit's tibia. After implantation for predetermined periods up to 16 weeks, the specimens were extracted with bone tissue, and were examined by push-out test to evaluate the shearing force between the implant and bone tissue. The results were compared with those of non-treated pure titanium. Eight weeks after surgery, the shearing force of the treated titanium implanted in the 4.2mm-hole was significantly higher than that of non-treated titanium, although the surface roughness was not changed after the treatment. Scanning electron microscopic (SEM) observation and energy-dispersive X-ray (EDX) microanalysis showed that the bone comes very close to the surface of the treated titanium. Moreover, the shearing force was higher for the implanted sample in the 4.0mm-hole than that in the 4.2mm-hole. Thus, it is confirmed that the treatment with hydrogen peroxide solution containing tantalum chloride provides higher bonding ability on titanium implants in vivo.
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UR - http://www.scopus.com/inward/citedby.url?scp=0035342607&partnerID=8YFLogxK
U2 - 10.1016/S0142-9612(01)00036-9
DO - 10.1016/S0142-9612(01)00036-9
M3 - Article
C2 - 11311005
AN - SCOPUS:0035342607
VL - 22
SP - 875
EP - 881
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 9
ER -