In vivo gene transfer of soluble TNF-alpha receptor 1 alleviates myocardial infarction.

Masahiro Sugano, Masamichi Koyanagi, Keiko Tsuchida, Tomoji Hata, Naoki Makino

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Apoptosis is the major independent form of cardiomyocyte cell death in acute myocardial infarction (AMI). TNF-alpha release early in the course of AMI contributes to myocardial injury, and TNF-alpha induces apoptosis in cardiomyocytes. Soluble TNF-alpha receptor 1 (sTNFR1) is an antagonist to TNF-alpha. However, the effect of sTNFR1 on AMI remains unclear. Here we report that direct injection of an sTNFR1 expression plasmid DNA to the myocardium reduces infarct size in experimental rat AMI. Treatment with sTNFR1 expression plasmid DNA reduced the TNF-alpha bioactivity in the myocardium and the apoptosis of cardiomyocytes. These findings suggest that the anti-TNF-alpha therapy by sTNFR1 can be a new strategy for treatment of AMI.

Original languageEnglish
Pages (from-to)1421-1422
Number of pages2
JournalThe FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume16
Issue number11
Publication statusPublished - Jan 1 2002

Fingerprint

Gene transfer
Tumor Necrosis Factor Receptors
Tumor Necrosis Factor-alpha
Myocardial Infarction
Genes
Cardiac Myocytes
Apoptosis
Myocardium
Plasmids
DNA
Direct injection
Cell death
Bioactivity
Rats
Cell Death
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

In vivo gene transfer of soluble TNF-alpha receptor 1 alleviates myocardial infarction. / Sugano, Masahiro; Koyanagi, Masamichi; Tsuchida, Keiko; Hata, Tomoji; Makino, Naoki.

In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 16, No. 11, 01.01.2002, p. 1421-1422.

Research output: Contribution to journalArticle

Sugano, Masahiro ; Koyanagi, Masamichi ; Tsuchida, Keiko ; Hata, Tomoji ; Makino, Naoki. / In vivo gene transfer of soluble TNF-alpha receptor 1 alleviates myocardial infarction. In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2002 ; Vol. 16, No. 11. pp. 1421-1422.
@article{7b5f9b58c34e4b7a992787a375cd555c,
title = "In vivo gene transfer of soluble TNF-alpha receptor 1 alleviates myocardial infarction.",
abstract = "Apoptosis is the major independent form of cardiomyocyte cell death in acute myocardial infarction (AMI). TNF-alpha release early in the course of AMI contributes to myocardial injury, and TNF-alpha induces apoptosis in cardiomyocytes. Soluble TNF-alpha receptor 1 (sTNFR1) is an antagonist to TNF-alpha. However, the effect of sTNFR1 on AMI remains unclear. Here we report that direct injection of an sTNFR1 expression plasmid DNA to the myocardium reduces infarct size in experimental rat AMI. Treatment with sTNFR1 expression plasmid DNA reduced the TNF-alpha bioactivity in the myocardium and the apoptosis of cardiomyocytes. These findings suggest that the anti-TNF-alpha therapy by sTNFR1 can be a new strategy for treatment of AMI.",
author = "Masahiro Sugano and Masamichi Koyanagi and Keiko Tsuchida and Tomoji Hata and Naoki Makino",
year = "2002",
month = "1",
day = "1",
language = "English",
volume = "16",
pages = "1421--1422",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "FASEB",
number = "11",

}

TY - JOUR

T1 - In vivo gene transfer of soluble TNF-alpha receptor 1 alleviates myocardial infarction.

AU - Sugano, Masahiro

AU - Koyanagi, Masamichi

AU - Tsuchida, Keiko

AU - Hata, Tomoji

AU - Makino, Naoki

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Apoptosis is the major independent form of cardiomyocyte cell death in acute myocardial infarction (AMI). TNF-alpha release early in the course of AMI contributes to myocardial injury, and TNF-alpha induces apoptosis in cardiomyocytes. Soluble TNF-alpha receptor 1 (sTNFR1) is an antagonist to TNF-alpha. However, the effect of sTNFR1 on AMI remains unclear. Here we report that direct injection of an sTNFR1 expression plasmid DNA to the myocardium reduces infarct size in experimental rat AMI. Treatment with sTNFR1 expression plasmid DNA reduced the TNF-alpha bioactivity in the myocardium and the apoptosis of cardiomyocytes. These findings suggest that the anti-TNF-alpha therapy by sTNFR1 can be a new strategy for treatment of AMI.

AB - Apoptosis is the major independent form of cardiomyocyte cell death in acute myocardial infarction (AMI). TNF-alpha release early in the course of AMI contributes to myocardial injury, and TNF-alpha induces apoptosis in cardiomyocytes. Soluble TNF-alpha receptor 1 (sTNFR1) is an antagonist to TNF-alpha. However, the effect of sTNFR1 on AMI remains unclear. Here we report that direct injection of an sTNFR1 expression plasmid DNA to the myocardium reduces infarct size in experimental rat AMI. Treatment with sTNFR1 expression plasmid DNA reduced the TNF-alpha bioactivity in the myocardium and the apoptosis of cardiomyocytes. These findings suggest that the anti-TNF-alpha therapy by sTNFR1 can be a new strategy for treatment of AMI.

UR - http://www.scopus.com/inward/record.url?scp=0036719444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036719444&partnerID=8YFLogxK

M3 - Article

C2 - 12205034

AN - SCOPUS:0036719444

VL - 16

SP - 1421

EP - 1422

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 11

ER -