In vivo magnetic resonance imaging of single-walled carbon nanohorns by labeling with magnetite nanoparticles

Jin Miyawaki, Masako Yudasaka, Hideto Imai, Hideki Yorimitsu, Hiroyuki Isobe, Eiichi Nakamura, Sumio Iijima

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

The magnetite-attaching method that can be used with single-walled carbon nanohorns (SWNH) and allows in vivo magnetic resonance imaging (MRI) of various carbon nanotubes (CNT) to provide information needed for biomedical applications and assessing their toxicity, was investigated. The attached magnetite nanoparticles induced darkening of the MR images allowing in vivo visualization of the accumulative behavior of nanohorns (NHs) in the spleen and kidneys. The method is expected to facilitate health-risk assessment of various types of CNTs using in vivo MRI for fullerene derivatives. The information provided in the experiment is important for the fabrication of nanotubular carbonaceous materials that are designed for applications in biomedical science and biotechnologies.

Original languageEnglish
Pages (from-to)1010-1014
Number of pages5
JournalAdvanced Materials
Volume18
Issue number8
DOIs
Publication statusPublished - Apr 18 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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