In vivo monitoring of gold nanorods and tissue damage mediated with their photothermal effect

Takuro Niidome, Yasuyuki Akiyama, Kohei Shimoda, Takahito Kawano, Takeshi Mori, Yoshiki Katayama, Yasuro Niidome

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Gold nanorods have a strong surface plasmon band at the near infrared region. The absorbed light energy is then converted to heat. Since near infrared light can penetrate deeply into tissue, gold nanorods are expected to be used as a contrast agent for bioimaging using the near infrared light and photosensitizers for photothermal therapy. The surface plasmon bands of intravenously injected the gold nanorods were directly monitored from the mouse abdomen by using a spectrophotometer equipped with an integrating sphere. The absorbance at 900 nm from PEG5,000-modified gold nanorods immediately increased after injection and reached a plateau. The injection of phosphatidylcholine-modified gold nanorods also increased the absorbance at 900 nm, but the absorbance decreased single exponentially with a 1.3-min half-life. To demonstrate photothermal tumor therapy, the PEG-modified gold nanorods were directly injected into subcutaneous tumors in mice, then, near infrared laser light was irradiated to the tumor. After the treatment, significant suppression of tumor growth was observed.

Original languageEnglish
Title of host publicationNanofunctional Materials, Structures, and Devices for Biomedical Applications
Pages73-78
Number of pages6
Publication statusPublished - Dec 1 2009
Event2009 MRS Fall Meeting - Boston, MA, United States
Duration: Nov 29 2009Dec 3 2009

Publication series

NameMaterials Research Society Symposium Proceedings
Volume1138
ISSN (Print)0272-9172

Conference

Conference2009 MRS Fall Meeting
CountryUnited States
CityBoston, MA
Period11/29/0912/3/09

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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