Abstract
bold nanorods showing surface plasmon (SP) bands in the near-IR region are used as bioimaging probes that respond to near-IR light in mice. The SP bands of intravenously injected polyethylene gly col-modified gold nanorods are directly monitored from the mouse abdomen by using a spectrophotometer equipped with an integrating sphere. The absorbance at 900 nm from the gold nanorods immediately increases after injection and reaches a plateau. The injection of phosphatidylcholine-modified gold nanorods also increases the absorbance at 900 nm, but the absorbance decreases single exponentially with a 1.3-min half-life. In vivo spectral changes of gold nanorods depend on the surface characteristics, and can be observed in real time using simple spectroscopic measurements.
| Original language | English |
|---|---|
| Pages (from-to) | 1001-1007 |
| Number of pages | 7 |
| Journal | Small |
| Volume | 4 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1 2008 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Biomaterials
- Chemistry(all)
- Materials Science(all)
- Engineering (miscellaneous)
Cite this
In vivo monitoring of intravenously injected gold nanorods using near-infrared light. / Niidome, Takuro; Akiyama, Yasuyuki; Shimoda, Kohei; Kawano, Takahito; Mori, Takeshi; Katayama, Yoshiki; Niidome, Yasuro.
In: Small, Vol. 4, No. 7, 01.07.2008, p. 1001-1007.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo monitoring of intravenously injected gold nanorods using near-infrared light
AU - Niidome, Takuro
AU - Akiyama, Yasuyuki
AU - Shimoda, Kohei
AU - Kawano, Takahito
AU - Mori, Takeshi
AU - Katayama, Yoshiki
AU - Niidome, Yasuro
PY - 2008/7/1
Y1 - 2008/7/1
N2 - bold nanorods showing surface plasmon (SP) bands in the near-IR region are used as bioimaging probes that respond to near-IR light in mice. The SP bands of intravenously injected polyethylene gly col-modified gold nanorods are directly monitored from the mouse abdomen by using a spectrophotometer equipped with an integrating sphere. The absorbance at 900 nm from the gold nanorods immediately increases after injection and reaches a plateau. The injection of phosphatidylcholine-modified gold nanorods also increases the absorbance at 900 nm, but the absorbance decreases single exponentially with a 1.3-min half-life. In vivo spectral changes of gold nanorods depend on the surface characteristics, and can be observed in real time using simple spectroscopic measurements.
AB - bold nanorods showing surface plasmon (SP) bands in the near-IR region are used as bioimaging probes that respond to near-IR light in mice. The SP bands of intravenously injected polyethylene gly col-modified gold nanorods are directly monitored from the mouse abdomen by using a spectrophotometer equipped with an integrating sphere. The absorbance at 900 nm from the gold nanorods immediately increases after injection and reaches a plateau. The injection of phosphatidylcholine-modified gold nanorods also increases the absorbance at 900 nm, but the absorbance decreases single exponentially with a 1.3-min half-life. In vivo spectral changes of gold nanorods depend on the surface characteristics, and can be observed in real time using simple spectroscopic measurements.
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UR - http://www.scopus.com/inward/citedby.url?scp=48249153796&partnerID=8YFLogxK
U2 - 10.1002/smll.200700438
DO - 10.1002/smll.200700438
M3 - Article
C2 - 18581412
AN - SCOPUS:48249153796
VL - 4
SP - 1001
EP - 1007
JO - Small
JF - Small
SN - 1613-6810
IS - 7
ER -