In vivo monitoring of intravenously injected gold nanorods using near-infrared light

Takuro Niidome, Yasuyuki Akiyama, Kohei Shimoda, Takahito Kawano, Takeshi Mori, Yoshiki Katayama, Yasuro Niidome

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49 Citations (Scopus)

Abstract

bold nanorods showing surface plasmon (SP) bands in the near-IR region are used as bioimaging probes that respond to near-IR light in mice. The SP bands of intravenously injected polyethylene gly col-modified gold nanorods are directly monitored from the mouse abdomen by using a spectrophotometer equipped with an integrating sphere. The absorbance at 900 nm from the gold nanorods immediately increases after injection and reaches a plateau. The injection of phosphatidylcholine-modified gold nanorods also increases the absorbance at 900 nm, but the absorbance decreases single exponentially with a 1.3-min half-life. In vivo spectral changes of gold nanorods depend on the surface characteristics, and can be observed in real time using simple spectroscopic measurements.

Original languageEnglish
Pages (from-to)1001-1007
Number of pages7
JournalSmall
Volume4
Issue number7
DOIs
Publication statusPublished - Jul 1 2008

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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