In vivo monitoring of intravenously injected gold nanorods using near-infrared light

Takuro Niidome, Yasuyuki Akiyama, Kohei Shimoda, Takahito Kawano, Takeshi Mori, Yoshiki Katayama, Yasuro Niidome

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

bold nanorods showing surface plasmon (SP) bands in the near-IR region are used as bioimaging probes that respond to near-IR light in mice. The SP bands of intravenously injected polyethylene gly col-modified gold nanorods are directly monitored from the mouse abdomen by using a spectrophotometer equipped with an integrating sphere. The absorbance at 900 nm from the gold nanorods immediately increases after injection and reaches a plateau. The injection of phosphatidylcholine-modified gold nanorods also increases the absorbance at 900 nm, but the absorbance decreases single exponentially with a 1.3-min half-life. In vivo spectral changes of gold nanorods depend on the surface characteristics, and can be observed in real time using simple spectroscopic measurements.

Original languageEnglish
Pages (from-to)1001-1007
Number of pages7
JournalSmall
Volume4
Issue number7
DOIs
Publication statusPublished - Jul 1 2008

Fingerprint

Nanotubes
Nanorods
Gold
Infrared radiation
Light
Monitoring
Injections
Spectrophotometers
Polyethylene
Phosphatidylcholines
Abdomen
Half-Life
Polyethylenes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)
  • Engineering (miscellaneous)

Cite this

In vivo monitoring of intravenously injected gold nanorods using near-infrared light. / Niidome, Takuro; Akiyama, Yasuyuki; Shimoda, Kohei; Kawano, Takahito; Mori, Takeshi; Katayama, Yoshiki; Niidome, Yasuro.

In: Small, Vol. 4, No. 7, 01.07.2008, p. 1001-1007.

Research output: Contribution to journalArticle

Niidome, T, Akiyama, Y, Shimoda, K, Kawano, T, Mori, T, Katayama, Y & Niidome, Y 2008, 'In vivo monitoring of intravenously injected gold nanorods using near-infrared light', Small, vol. 4, no. 7, pp. 1001-1007. https://doi.org/10.1002/smll.200700438
Niidome, Takuro ; Akiyama, Yasuyuki ; Shimoda, Kohei ; Kawano, Takahito ; Mori, Takeshi ; Katayama, Yoshiki ; Niidome, Yasuro. / In vivo monitoring of intravenously injected gold nanorods using near-infrared light. In: Small. 2008 ; Vol. 4, No. 7. pp. 1001-1007.
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