Abstract
bold nanorods showing surface plasmon (SP) bands in the near-IR region are used as bioimaging probes that respond to near-IR light in mice. The SP bands of intravenously injected polyethylene gly col-modified gold nanorods are directly monitored from the mouse abdomen by using a spectrophotometer equipped with an integrating sphere. The absorbance at 900 nm from the gold nanorods immediately increases after injection and reaches a plateau. The injection of phosphatidylcholine-modified gold nanorods also increases the absorbance at 900 nm, but the absorbance decreases single exponentially with a 1.3-min half-life. In vivo spectral changes of gold nanorods depend on the surface characteristics, and can be observed in real time using simple spectroscopic measurements.
Original language | English |
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Pages (from-to) | 1001-1007 |
Number of pages | 7 |
Journal | Small |
Volume | 4 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 1 2008 |
All Science Journal Classification (ASJC) codes
- Biotechnology
- Biomaterials
- Chemistry(all)
- Materials Science(all)