In vivo setting behaviour of fast-setting calcium phosphate cement

Youji Miyamoto, Kunio Ishikawa, Hirokazu Fukao, Masahiro Sawada, Masaru Nagayama, Masayuki Kon, Kenzo Asaoka

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

The in vivo setting behaviour of fast-setting calcium phosphate cement (FSCPC) between femoral muscles of the rat was investigated to evaluate the possible value of FSCPC for medical and dental application. Conventional CPC (c-CPC) and FSCPC were implanted between femoral muscles, and various aspects of the setting behaviour such as setting time, mechanical strength and conversion ratio of cement into hydroxyapatite (HAP: Ca10(PO4)6(OH)2) were measured by the Vicat needle method, diametral tensile strength (DTS) measurement, and quantitative powder X-ray diffraction (XRD) analysis, respectively. The setting time of FSCPC in vivo was 5-7 min, in contrast to 48 min for c-CPC. As a result of its fast setting, set specimens of FSCPC showed higher mechanical strength from the initial stage than c-CPC. Higher DTS values were observed in FSCPC than c-CPC implanted after 24 h. Powder XRD analysis revealed faster conversion of FSCPC than c-CPC into HAP, which was responsible both for the faster setting and higher mechanical strength from the initial stage. We concluded, therefore, that FSCPC may be used for a wide range of clinical applications, i.e. fields where fast setting is required such as orthopaedic, plastic and reconstructive, and oral and maxillo-facial surgery.

Original languageEnglish
Pages (from-to)855-860
Number of pages6
JournalBiomaterials
Volume16
Issue number11
DOIs
Publication statusPublished - Jan 1 1995
Externally publishedYes

Fingerprint

Calcium phosphate
Cements
Strength of materials
Tensile Strength
Thigh
X-Ray Diffraction
Powders
X ray diffraction analysis
Muscle
Tensile strength
Dental Cements
Muscles
Bone cement
calcium phosphate
Orthopedics
Hydroxyapatite
Needles
Durapatite
Surgery
Plastics

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Miyamoto, Y., Ishikawa, K., Fukao, H., Sawada, M., Nagayama, M., Kon, M., & Asaoka, K. (1995). In vivo setting behaviour of fast-setting calcium phosphate cement. Biomaterials, 16(11), 855-860. https://doi.org/10.1016/0142-9612(95)94147-D

In vivo setting behaviour of fast-setting calcium phosphate cement. / Miyamoto, Youji; Ishikawa, Kunio; Fukao, Hirokazu; Sawada, Masahiro; Nagayama, Masaru; Kon, Masayuki; Asaoka, Kenzo.

In: Biomaterials, Vol. 16, No. 11, 01.01.1995, p. 855-860.

Research output: Contribution to journalArticle

Miyamoto, Y, Ishikawa, K, Fukao, H, Sawada, M, Nagayama, M, Kon, M & Asaoka, K 1995, 'In vivo setting behaviour of fast-setting calcium phosphate cement', Biomaterials, vol. 16, no. 11, pp. 855-860. https://doi.org/10.1016/0142-9612(95)94147-D
Miyamoto, Youji ; Ishikawa, Kunio ; Fukao, Hirokazu ; Sawada, Masahiro ; Nagayama, Masaru ; Kon, Masayuki ; Asaoka, Kenzo. / In vivo setting behaviour of fast-setting calcium phosphate cement. In: Biomaterials. 1995 ; Vol. 16, No. 11. pp. 855-860.
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