In vivo siRNA delivery with dendritic poly(l-lysine) for the treatment of hypercholesterolemia

Kazuto Watanabe, Mariko Harada-Shiba, Akira Suzuki, Risa Gokuden, Ryohsuke Kurihara, Yusuke Sugao, Takeshi Mori, Yoshiki Katayama, Takuro Niidome

    Research output: Contribution to journalArticlepeer-review

    69 Citations (Scopus)

    Abstract

    Intravenous delivery of apolipoprotein B-specific siRNA with a sixth-generation of dendritic poly(l-lysine) (KG6) resulted in siRNA-mediated knockdown of ApoB in healthy C57BL/6 mice without hepatotoxicity, and with a significant reduction of serum low-density lipoprotein cholesterol in apolipoprotein E-deficient mice.

    Original languageEnglish
    Pages (from-to)1306-1310
    Number of pages5
    JournalMolecular BioSystems
    Volume5
    Issue number11
    DOIs
    Publication statusPublished - Oct 19 2009

    All Science Journal Classification (ASJC) codes

    • Biotechnology
    • Molecular Biology

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