TY - JOUR
T1 - Inactivating potassium currents in apical and basal turn inner hair cells from guinea-pig cochlea
AU - Kimitsuki, Takashi
AU - Nawate, Ayako
AU - Kakazu, Yasuhiro
AU - Matsumoto, Nozomu
AU - Takaiwa, Kazutaka
AU - Komune, Noritaka
AU - Noda, Teppei
AU - Komune, Shizuo
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research 9591978 from the Ministry of Education, Culture, Sports, Science and Technology of Japan and the Research Fund of Institute of Kampo Medicine (Japan).
PY - 2008/9/4
Y1 - 2008/9/4
N2 - Tetraethylammonium (TEA)-sensitive potassium currents in the cochlear inner hair cells (IHCs) possess the kinetics of fast inactivation. IHCs of guinea-pigs were separately isolated from the apical and basal turns and the tonotopic gradient of inactivation kinetics was investigated. TEA-sensitive potassium currents showed voltage-dependent time constant of the inactivation phase both in apical and basal IHCs, however, the degree of inactivation (compared to the ratio between the steady-state current and initial peak current) was voltage-independent. Inactivation time constant was faster in basal IHCs than in apical IHCs and the degree of inactivation was greater in basal IHCs than in apical IHCs, suggesting that inactivation was more predominant in basal IHCs than in apical IHCs.
AB - Tetraethylammonium (TEA)-sensitive potassium currents in the cochlear inner hair cells (IHCs) possess the kinetics of fast inactivation. IHCs of guinea-pigs were separately isolated from the apical and basal turns and the tonotopic gradient of inactivation kinetics was investigated. TEA-sensitive potassium currents showed voltage-dependent time constant of the inactivation phase both in apical and basal IHCs, however, the degree of inactivation (compared to the ratio between the steady-state current and initial peak current) was voltage-independent. Inactivation time constant was faster in basal IHCs than in apical IHCs and the degree of inactivation was greater in basal IHCs than in apical IHCs, suggesting that inactivation was more predominant in basal IHCs than in apical IHCs.
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U2 - 10.1016/j.brainres.2008.06.068
DO - 10.1016/j.brainres.2008.06.068
M3 - Article
C2 - 18619421
AN - SCOPUS:49349115784
SN - 0006-8993
VL - 1228
SP - 68
EP - 72
JO - Molecular Brain Research
JF - Molecular Brain Research
ER -