Inactivating potassium currents in apical and basal turn inner hair cells from guinea-pig cochlea

Takashi Kimitsuki, Ayako Nawate, Yasuhiro Kakazu, Nozomu Matsumoto, Kazutaka Takaiwa, Noritaka Komune, teppei noda, Shizuo Komune

Research output: Contribution to journalArticle

Abstract

Tetraethylammonium (TEA)-sensitive potassium currents in the cochlear inner hair cells (IHCs) possess the kinetics of fast inactivation. IHCs of guinea-pigs were separately isolated from the apical and basal turns and the tonotopic gradient of inactivation kinetics was investigated. TEA-sensitive potassium currents showed voltage-dependent time constant of the inactivation phase both in apical and basal IHCs, however, the degree of inactivation (compared to the ratio between the steady-state current and initial peak current) was voltage-independent. Inactivation time constant was faster in basal IHCs than in apical IHCs and the degree of inactivation was greater in basal IHCs than in apical IHCs, suggesting that inactivation was more predominant in basal IHCs than in apical IHCs.

Original languageEnglish
Pages (from-to)68-72
Number of pages5
JournalBrain Research
Volume1228
DOIs
Publication statusPublished - Sep 4 2008
Externally publishedYes

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Inner Auditory Hair Cells
Cochlea
Potassium
Guinea Pigs
Tetraethylammonium

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Inactivating potassium currents in apical and basal turn inner hair cells from guinea-pig cochlea. / Kimitsuki, Takashi; Nawate, Ayako; Kakazu, Yasuhiro; Matsumoto, Nozomu; Takaiwa, Kazutaka; Komune, Noritaka; noda, teppei; Komune, Shizuo.

In: Brain Research, Vol. 1228, 04.09.2008, p. 68-72.

Research output: Contribution to journalArticle

Kimitsuki, Takashi ; Nawate, Ayako ; Kakazu, Yasuhiro ; Matsumoto, Nozomu ; Takaiwa, Kazutaka ; Komune, Noritaka ; noda, teppei ; Komune, Shizuo. / Inactivating potassium currents in apical and basal turn inner hair cells from guinea-pig cochlea. In: Brain Research. 2008 ; Vol. 1228. pp. 68-72.
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