Incidence and predictors of ischemic stroke events during hospitalization in patients with transient ischemic attack

Jun Fujinami, Toshiyuki Uehara, Kazumi Kimura, Yasushi Okada, Yasuhiro Hasegawa, Norio Tanahashi, Akifumi Suzuki, Shigeharu Takagi, Jyoji Nakagawara, Kazumasa Arii, Shinji Nagahiro, Kuniaki Ogasawara, Takehiko Nagao, Shinichiro Uchiyama, Masayasu Matsumoto, Koji Iihara, Kazuo Minematsu

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Background: The purpose of this study was to elucidate the incidence and predictors of ischemic stroke or recurrent transient ischemic attack (TIA) during acute hospitalization in patients with TIA. Methods: We carried out a multicenter retrospective study to clarify the characteristics of in-patients with TIA. The subjects of this study were TIA patients admitted to 13 stroke hospitals within 7 days after onset between 2008 and 2009. TIA was defined as focal neurologic symptoms ascribable to a vascular etiology lasting less than 24 h. We investigated the incidence and predictors of ischemic events including ischemic stroke or recurrent TIA during hospitalization. Results: A total of 464 patients with TIA (292 men, 69 ± 13 years) were registered. Of those, 400 (86.2%) were admitted within 24 h of TIA onset. The mean length of hospital stay was 13 days. During hospitalization, 8 patients had ischemic strokes and 26 had recurrent TIAs. The leading subtype of 8 ischemic strokes was small vessel disease (n = 3) followed by cardioembolism (n = 2). Multiple logistic regression analysis showed that hypertension (OR: 3.41; 95% CI: 1.23-12.3), MRI-diffusion-weighted image positivity (OR: 2.49; 95% CI: 1.15-5.25), and hemiparesis (OR: 2.30; 95% CI: 1.02-5.88) were independently associated with ischemic events during hospitalization. Conclusions: In this study, 1.7% of patients with TIA had ischemic stroke during acute hospitalization, and the most common subtype was small vessel disease. Subsequent ischemic stroke and recurrent TIA were associated with hypertension, positive DWI findings, and hemiparesis.

Original languageEnglish
Pages (from-to)330-335
Number of pages6
JournalCerebrovascular Diseases
Volume37
Issue number5
DOIs
Publication statusPublished - 2014
Externally publishedYes

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Transient Ischemic Attack
Hospitalization
Stroke
Incidence
Paresis
Length of Stay
Hypertension
Diffusion Magnetic Resonance Imaging
Neurologic Manifestations
Multicenter Studies
Blood Vessels
Retrospective Studies
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Fujinami, J., Uehara, T., Kimura, K., Okada, Y., Hasegawa, Y., Tanahashi, N., ... Minematsu, K. (2014). Incidence and predictors of ischemic stroke events during hospitalization in patients with transient ischemic attack. Cerebrovascular Diseases, 37(5), 330-335. https://doi.org/10.1159/000360757

Incidence and predictors of ischemic stroke events during hospitalization in patients with transient ischemic attack. / Fujinami, Jun; Uehara, Toshiyuki; Kimura, Kazumi; Okada, Yasushi; Hasegawa, Yasuhiro; Tanahashi, Norio; Suzuki, Akifumi; Takagi, Shigeharu; Nakagawara, Jyoji; Arii, Kazumasa; Nagahiro, Shinji; Ogasawara, Kuniaki; Nagao, Takehiko; Uchiyama, Shinichiro; Matsumoto, Masayasu; Iihara, Koji; Minematsu, Kazuo.

In: Cerebrovascular Diseases, Vol. 37, No. 5, 2014, p. 330-335.

Research output: Contribution to journalReview article

Fujinami, J, Uehara, T, Kimura, K, Okada, Y, Hasegawa, Y, Tanahashi, N, Suzuki, A, Takagi, S, Nakagawara, J, Arii, K, Nagahiro, S, Ogasawara, K, Nagao, T, Uchiyama, S, Matsumoto, M, Iihara, K & Minematsu, K 2014, 'Incidence and predictors of ischemic stroke events during hospitalization in patients with transient ischemic attack', Cerebrovascular Diseases, vol. 37, no. 5, pp. 330-335. https://doi.org/10.1159/000360757
Fujinami, Jun ; Uehara, Toshiyuki ; Kimura, Kazumi ; Okada, Yasushi ; Hasegawa, Yasuhiro ; Tanahashi, Norio ; Suzuki, Akifumi ; Takagi, Shigeharu ; Nakagawara, Jyoji ; Arii, Kazumasa ; Nagahiro, Shinji ; Ogasawara, Kuniaki ; Nagao, Takehiko ; Uchiyama, Shinichiro ; Matsumoto, Masayasu ; Iihara, Koji ; Minematsu, Kazuo. / Incidence and predictors of ischemic stroke events during hospitalization in patients with transient ischemic attack. In: Cerebrovascular Diseases. 2014 ; Vol. 37, No. 5. pp. 330-335.
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abstract = "Background: The purpose of this study was to elucidate the incidence and predictors of ischemic stroke or recurrent transient ischemic attack (TIA) during acute hospitalization in patients with TIA. Methods: We carried out a multicenter retrospective study to clarify the characteristics of in-patients with TIA. The subjects of this study were TIA patients admitted to 13 stroke hospitals within 7 days after onset between 2008 and 2009. TIA was defined as focal neurologic symptoms ascribable to a vascular etiology lasting less than 24 h. We investigated the incidence and predictors of ischemic events including ischemic stroke or recurrent TIA during hospitalization. Results: A total of 464 patients with TIA (292 men, 69 ± 13 years) were registered. Of those, 400 (86.2{\%}) were admitted within 24 h of TIA onset. The mean length of hospital stay was 13 days. During hospitalization, 8 patients had ischemic strokes and 26 had recurrent TIAs. The leading subtype of 8 ischemic strokes was small vessel disease (n = 3) followed by cardioembolism (n = 2). Multiple logistic regression analysis showed that hypertension (OR: 3.41; 95{\%} CI: 1.23-12.3), MRI-diffusion-weighted image positivity (OR: 2.49; 95{\%} CI: 1.15-5.25), and hemiparesis (OR: 2.30; 95{\%} CI: 1.02-5.88) were independently associated with ischemic events during hospitalization. Conclusions: In this study, 1.7{\%} of patients with TIA had ischemic stroke during acute hospitalization, and the most common subtype was small vessel disease. Subsequent ischemic stroke and recurrent TIA were associated with hypertension, positive DWI findings, and hemiparesis.",
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T1 - Incidence and predictors of ischemic stroke events during hospitalization in patients with transient ischemic attack

AU - Fujinami, Jun

AU - Uehara, Toshiyuki

AU - Kimura, Kazumi

AU - Okada, Yasushi

AU - Hasegawa, Yasuhiro

AU - Tanahashi, Norio

AU - Suzuki, Akifumi

AU - Takagi, Shigeharu

AU - Nakagawara, Jyoji

AU - Arii, Kazumasa

AU - Nagahiro, Shinji

AU - Ogasawara, Kuniaki

AU - Nagao, Takehiko

AU - Uchiyama, Shinichiro

AU - Matsumoto, Masayasu

AU - Iihara, Koji

AU - Minematsu, Kazuo

PY - 2014

Y1 - 2014

N2 - Background: The purpose of this study was to elucidate the incidence and predictors of ischemic stroke or recurrent transient ischemic attack (TIA) during acute hospitalization in patients with TIA. Methods: We carried out a multicenter retrospective study to clarify the characteristics of in-patients with TIA. The subjects of this study were TIA patients admitted to 13 stroke hospitals within 7 days after onset between 2008 and 2009. TIA was defined as focal neurologic symptoms ascribable to a vascular etiology lasting less than 24 h. We investigated the incidence and predictors of ischemic events including ischemic stroke or recurrent TIA during hospitalization. Results: A total of 464 patients with TIA (292 men, 69 ± 13 years) were registered. Of those, 400 (86.2%) were admitted within 24 h of TIA onset. The mean length of hospital stay was 13 days. During hospitalization, 8 patients had ischemic strokes and 26 had recurrent TIAs. The leading subtype of 8 ischemic strokes was small vessel disease (n = 3) followed by cardioembolism (n = 2). Multiple logistic regression analysis showed that hypertension (OR: 3.41; 95% CI: 1.23-12.3), MRI-diffusion-weighted image positivity (OR: 2.49; 95% CI: 1.15-5.25), and hemiparesis (OR: 2.30; 95% CI: 1.02-5.88) were independently associated with ischemic events during hospitalization. Conclusions: In this study, 1.7% of patients with TIA had ischemic stroke during acute hospitalization, and the most common subtype was small vessel disease. Subsequent ischemic stroke and recurrent TIA were associated with hypertension, positive DWI findings, and hemiparesis.

AB - Background: The purpose of this study was to elucidate the incidence and predictors of ischemic stroke or recurrent transient ischemic attack (TIA) during acute hospitalization in patients with TIA. Methods: We carried out a multicenter retrospective study to clarify the characteristics of in-patients with TIA. The subjects of this study were TIA patients admitted to 13 stroke hospitals within 7 days after onset between 2008 and 2009. TIA was defined as focal neurologic symptoms ascribable to a vascular etiology lasting less than 24 h. We investigated the incidence and predictors of ischemic events including ischemic stroke or recurrent TIA during hospitalization. Results: A total of 464 patients with TIA (292 men, 69 ± 13 years) were registered. Of those, 400 (86.2%) were admitted within 24 h of TIA onset. The mean length of hospital stay was 13 days. During hospitalization, 8 patients had ischemic strokes and 26 had recurrent TIAs. The leading subtype of 8 ischemic strokes was small vessel disease (n = 3) followed by cardioembolism (n = 2). Multiple logistic regression analysis showed that hypertension (OR: 3.41; 95% CI: 1.23-12.3), MRI-diffusion-weighted image positivity (OR: 2.49; 95% CI: 1.15-5.25), and hemiparesis (OR: 2.30; 95% CI: 1.02-5.88) were independently associated with ischemic events during hospitalization. Conclusions: In this study, 1.7% of patients with TIA had ischemic stroke during acute hospitalization, and the most common subtype was small vessel disease. Subsequent ischemic stroke and recurrent TIA were associated with hypertension, positive DWI findings, and hemiparesis.

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