Incidence rate of injection-site granulomas resulting from the administration of Luteinizing hormone-releasing hormone analogues for the treatment of prostatic cancer

Masaki Shiota, Noriaki Tokuda, Takehiro Kanou, Humio Yamasaki

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: Granulomas resulting from the administration of luteinizing hormone-releasing hormone analogues (LH-RH analogues) are thought to be very rare. We report on our clinical experience with injection-site granulomas that result from the administration of LH-RH analogues, and we evaluate the incidence rate of these granulomas. Materials and Methods: We used the clinical records of 118 patients who were administered LH-RH analogues in 2005. We describe the clinical data of patients who experienced injection-site granulomas and evaluated the incidence rate. Results: Five patients demonstrated mjection-site granulomas due to LH-RH analogue administration. The incidence rate was 4.2% (5 of 118 patients). Most of the granulomas occurred after the first or second administration of 11.25 mg of leuprorelin acetate. Conclusion: The occurrence of granulomas resulting from the administration of LH-RH analogues was thought to be very rare. Our study, however, revealed a higher incidence rate than expected, especially for leuprorelin acetate.

Original languageEnglish
Pages (from-to)421-424
Number of pages4
JournalYonsei Medical Journal
Volume48
Issue number3
DOIs
Publication statusPublished - Jun 1 2007

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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