Incidentally proven pulmonary "AlKoma"

Atsushi Osoegawa, Kaname Nosaki, Hitoshi Miyamoto, Takuro Kometani, Fumihiko Hirai, Kaoru Ondo, Takashi Seto, Kenji Sugio, Young Lim Choi, Manabu Soda, Hiroyuki Mano, Yukito Ichinose

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Genetic alterations of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inversion were recently found in lung cancer. A 39-year-old woman with multiple brain metastases and bulky mediastinal lymph node metastases was admitted. Biopsy from her supraclavicular lymph nodes was performed to differentiate the diagnosis between lymphoma and lung cancer. Pathologically, the lymph nodes had a feature of adenocarcinoma. On the other hand, the commercially available chromosomal fluorescent in situ hybridization (FISH) analysis showed split signals of ALK, which was confirmed to be the EML4-ALK inversion. The commercial-based ALK FISH is useful for screening pulmonary ALKoma.

Original languageEnglish
Pages (from-to)603-606
Number of pages4
JournalInternal Medicine
Issue number6
Publication statusPublished - Mar 15 2010

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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