Incidentally proven pulmonary "AlKoma"

Atsushi Osoegawa; Kaname Nosaki; Hitoshi Miyamoto; Takuro Kometani; Fumihiko Hirai; Kaoru Ondo; Takashi Seto; Kenji Sugio; Young Lim Choi; Manabu Soda; Hiroyuki Mano; Yukito Ichinose

doi:10.2169/internalmedicine.49.3126

Incidentally proven pulmonary "AlKoma"

Atsushi Osoegawa, Kaname Nosaki, Hitoshi Miyamoto, Takuro Kometani, Fumihiko Hirai, Kaoru Ondo, Takashi Seto, Kenji Sugio, Young Lim Choi, Manabu Soda, Hiroyuki Mano, Yukito Ichinose

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Genetic alterations of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inversion were recently found in lung cancer. A 39-year-old woman with multiple brain metastases and bulky mediastinal lymph node metastases was admitted. Biopsy from her supraclavicular lymph nodes was performed to differentiate the diagnosis between lymphoma and lung cancer. Pathologically, the lymph nodes had a feature of adenocarcinoma. On the other hand, the commercially available chromosomal fluorescent in situ hybridization (FISH) analysis showed split signals of ALK, which was confirmed to be the EML4-ALK inversion. The commercial-based ALK FISH is useful for screening pulmonary ALKoma.

Original language	English
Pages (from-to)	603-606
Number of pages	4
Journal	Internal Medicine
Volume	49
Issue number	6
DOIs	https://doi.org/10.2169/internalmedicine.49.3126
Publication status	Published - Mar 15 2010

All Science Journal Classification (ASJC) codes

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2169/internalmedicine.49.3126

Cite this

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title = "Incidentally proven pulmonary {"}AlKoma{"}",

abstract = "Genetic alterations of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inversion were recently found in lung cancer. A 39-year-old woman with multiple brain metastases and bulky mediastinal lymph node metastases was admitted. Biopsy from her supraclavicular lymph nodes was performed to differentiate the diagnosis between lymphoma and lung cancer. Pathologically, the lymph nodes had a feature of adenocarcinoma. On the other hand, the commercially available chromosomal fluorescent in situ hybridization (FISH) analysis showed split signals of ALK, which was confirmed to be the EML4-ALK inversion. The commercial-based ALK FISH is useful for screening pulmonary ALKoma.",

author = "Atsushi Osoegawa and Kaname Nosaki and Hitoshi Miyamoto and Takuro Kometani and Fumihiko Hirai and Kaoru Ondo and Takashi Seto and Kenji Sugio and Choi, {Young Lim} and Manabu Soda and Hiroyuki Mano and Yukito Ichinose",

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T1 - Incidentally proven pulmonary "AlKoma"

AU - Osoegawa, Atsushi

AU - Nosaki, Kaname

AU - Miyamoto, Hitoshi

AU - Kometani, Takuro

AU - Hirai, Fumihiko

AU - Ondo, Kaoru

AU - Seto, Takashi

AU - Sugio, Kenji

AU - Choi, Young Lim

AU - Soda, Manabu

AU - Mano, Hiroyuki

AU - Ichinose, Yukito

PY - 2010/3/15

Y1 - 2010/3/15

N2 - Genetic alterations of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inversion were recently found in lung cancer. A 39-year-old woman with multiple brain metastases and bulky mediastinal lymph node metastases was admitted. Biopsy from her supraclavicular lymph nodes was performed to differentiate the diagnosis between lymphoma and lung cancer. Pathologically, the lymph nodes had a feature of adenocarcinoma. On the other hand, the commercially available chromosomal fluorescent in situ hybridization (FISH) analysis showed split signals of ALK, which was confirmed to be the EML4-ALK inversion. The commercial-based ALK FISH is useful for screening pulmonary ALKoma.

AB - Genetic alterations of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inversion were recently found in lung cancer. A 39-year-old woman with multiple brain metastases and bulky mediastinal lymph node metastases was admitted. Biopsy from her supraclavicular lymph nodes was performed to differentiate the diagnosis between lymphoma and lung cancer. Pathologically, the lymph nodes had a feature of adenocarcinoma. On the other hand, the commercially available chromosomal fluorescent in situ hybridization (FISH) analysis showed split signals of ALK, which was confirmed to be the EML4-ALK inversion. The commercial-based ALK FISH is useful for screening pulmonary ALKoma.

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JF - Internal Medicine

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Incidentally proven pulmonary "AlKoma"

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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