Inclusion body myositis associated with hepatitis C virus infection.

Y. Tsuruta, T. Yamada, T. Yoshimura, M. Satake, K. Ogata, T. Yamamoto, H. Furuya, J. Kira

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Abstract

Inclusion body myositis (IBM) is a chronic progressive inflammatory myopathy in elders. Three patients with chronic hepatitis C developed IBM. Their muscle biopsies were examined by polymerase chain reaction (PCR) for two patients and immunohistochemistry for three patients. The hepatitis C virus (HCV)-RNA genome was detected in one of the two patients. The degenerated and atrophic muscle fibers were immunoreactive for an anti-HCV antibody in all three patients. Immunoreactivity for an anti-HCV antibody was not apparent in the muscle specimen from an IBM patient without HCV infection. Our findings suggest that HCV infection is related to the pathogenesis in some cases of IBM.

Original languageEnglish
Pages (from-to)370-376
Number of pages7
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume92
Issue number11
Publication statusPublished - Nov 2001

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Tsuruta, Y., Yamada, T., Yoshimura, T., Satake, M., Ogata, K., Yamamoto, T., Furuya, H., & Kira, J. (2001). Inclusion body myositis associated with hepatitis C virus infection. Fukuoka igaku zasshi = Hukuoka acta medica, 92(11), 370-376.